Shatorna V. F., Krasnov O. O.
THE INFLUENCE OF CADMIUM CHLORIDE ON THE MORPHOGENESIS OF KIDNEYS OF RAT EMBRYOS IN ISOLATED ADMINISTRATION AND ITS COMBINED EFFECT WITH METAL SUCCINATE
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About the author:
Shatorna V. F., Krasnov O. O.
Heading:
BIOLOGY
Type of article:
Scientific article
Annotation:
Environmental degradation has already become a global problem all over the world. The negative impact of ecopollutants on human health increasingly requires comprehensive research not only in medicine, pharmacy, agriculture, but also in morphological and biochemical experimental studies to determine pathological changes in morphogenesis and search for new potential bioantagonists to toxic substances in the environment. Morphological changes of nephrogenesis in rat embryos that were indirectly exposed to cadmium chloride through the mother's body were investigated in the work. The bioantagonistic characteristics of zinc and copper succinates of cadmium nephrotoxicity at their combined intake in an experiment on rats were also determined. The experiment was carried out on pregnant female rats, which received a daily intragastric solution of cadmium chloride alone or in combination with zinc or copper succinate. Morphological changes in the kidneys of rat embryos on the 13th and 19th days of the experiment were studied. The obtained results indisputably prove the nephrotoxicity of cadmium chloride in the indicated dose and method of administration in a chronic experiment on pregnant female rats. It has been proven that the isolated introduction of cadmium chloride provokes a significant expansion of the nephron capsule in the embryos of experimental animals, which occurs due to the formation of edema and a decrease in the area of the vascular body of the nephrons at the end of embryogenesis. In the groups of combined exposure to cadmium with copper or zinc succinates, the parameters of the nephron capsule cavity area were restored to the control data and were significantly lower than the group of isolated exposure to cadmium chloride, which allows us to consider zinc succinate and copper succinate as potential bioantagonists of cadmium chloride when combined in the experiment on rats.
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 208-217 pages, index UDC 616.61:591.3:546.48:612.6
