Mukvych V. V., Severynovska O. V.

MODULATORY EFFECT OF CAFFEINE ON HEART RATE VARIABILITY PARAMETERS IN RATS WITH DOXORUBICIN-INDUCED CARDIOMYOPATHY

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About the author:

Mukvych V. V., Severynovska O. V.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Caffeine is one of the most widely used psychoactive substances in the world. The caffeine physiological effect has both positive and negative aspects of influence on a living organism, which depends primarily on the dosage, individual sensitivity and initial characteristics of the body condition. With each passing year, the level of cancer is only increasing. According to scientists and doctors, the global cancer mortality rate may reach 15.3 million deaths annually by 2040. Doxorubicin is one of the leading chemotherapeutic drugs for treating various types of cancer. Despite its positive effects on the body when treating cancer, doxorubicin has significant side effects. The aim of our study was to investigate the effect of caffeine on heart rate variability in an experimental model of doxorubicin cardiomyopathy in rats to identify its potential cardioprotective effect and the ability to regulate the autonomic nervous system. The studies had been performed on white sexually mature male rats of three groups during a month. An electrocardiogram (ECG) was recorded in male rats and the heart rate variability (HRV) parameters were evaluated under the Baevsky’s Stress Index formula. The rats treated with doxorubicin showed a significant deterioration of the cardiovascular system, which was manifested in a significant increase or decrease in all HRV parameters studied by us and provided in this article. Male rats treated with caffeine in combination with doxorubicin showed a significant improvement in most HRV parameters, namely: HR, variation range, vegetative balance index, tension index, and coefficient of variation. Our HRV results indicate the possibility of using caffeine as a supportive agent to reduce the cardiotoxic side effects of chemotherapy in future clinical trials. They emphasize the importance of the HRV method in studying the effectiveness of therapeutic approaches and the autonomic nervous system regulation.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 433-441 pages, index UDC 616.127-008:547.857.4]:599.323.4

DOI:

10.29254/2077-4214-2024-4-175-433-441