SOME FEATURES OF THE ULTRASTRUCTURE OF THE ENDOTHELIUM AND CAPILLARIES OF MYOCARDIUM IN THE EARLY POSTNATAL DEVELOPMENT PERIOD OF WISTAR RATS

  2. 2023
  3. SOME FEATURES OF THE ULTRASTRUCTURE OF THE ENDOTHELIUM AND CAPILLARIES OF MYOCARDIUM IN THE EARLY POSTNATAL DEVELOPMENT PERIOD OF WISTAR RATS

Zahoruyko H. E., Marcynovskyi V. P., Tsventukh L. V., Tsaturyan O. H., Filatova V. L., Matvienko T. M., Sargosh O. D.

SOME FEATURES OF THE ULTRASTRUCTURE OF THE ENDOTHELIUM AND CAPILLARIES OF MYOCARDIUM IN THE EARLY POSTNATAL DEVELOPMENT PERIOD OF WISTAR RATS

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About the author:

Zahoruyko H. E., Marcynovskyi V. P., Tsventukh L. V., Tsaturyan O. H., Filatova V. L., Matvienko T. M., Sargosh O. D.

Heading:

BIOLOGY

Type of article:

Scientific article

Annotation:

The conducted studies demonstrate significant changes in the endothelium's ultrastructure and myocardium's blood capillaries during the postnatal development of Wistar rats. A series of images of the ultrastructure of the blood capillaries of the myocardium of the left ventricle of rats of various ages allowed us to obtain information for further development and theoretical substantiation of the origin, mechanisms of formation of some intravasal and paravasal vesicles, which are found in ultrathin sections of pieces of the myocardium of animals. The article analyzes the possible functions of processes and lamellae, which are located on the lumenal surface of the vascular endothelium of blood capillaries of the myocardium. The role of capillary erythrocytes in the formation and gradual elongation mechanisms of endotheliocyte cytoplasmic appendages, which later develop into blood capillary tubes, was investigated. Morphological manifestations of the development of physiological apoptosis of endotheliocytes in the blood capillaries of the myocardium of sheep were identified and investigated. It was established that a part of apoptotic bodies is adsorbed on the surface of erythrocytes. The obtained data suggest that erythrocytes participate in the adsorption and transport of apoptotic bodies on their surface from blood capillaries to the system of blood vessels. It has been suggested that the removal of apoptotic bodies from the blood and the surface of erythrocytes is mainly carried out by Kupffer macrophages of the liver. It has been established that in rats of various ages, the myocardium sometimes reveals morphological manifestations of diapedesis of erythrocytes from the capillaries into the connective tissue. The authors interpret diapedesis of erythrocytes as an additional mechanism of oxygen saturation of local areas of the myocardial stroma to prevent the possible development of hypoxia of the heart muscle of rats at the stages of postnatal ontogenesis.

Tags:

capillaries, diapedesis of erythrocytes, endothelium, myocardium

Bibliography:

  1. Dyumin MS, Pronin VV. Angiologia. Ivanovo: FGBOU; 2020. 103 s.
  2. Ribatti D, Nico B, Crivellato E. Morphological and molecular aspects of physiological vascular morphogenesis. Angiogenesis. 2009;12(2):101-111.
  3. Panysheva IA, Smirnov VP. Dinamika morfometricheskikh pokazateley izmeneniya funktsionalnogo elementa ishemizirovannogo miokarda. Molodoy uchenyy. 2017;5(139):88-92.
  4. Strukov AI, Syerov VV. Patolohichna anatomiya. Pidruchnyk (Per. z ros.). 4-ti vyd. Kharkiv: Stereotypne. Fakt; 2004. 864 s. [in Ukrainian].
  5. Zagoruyko GE, Martsinovsky VP, Husakovska TM, Filatova VL, Zagoruyko YuV. Kinetics of the development of the microcirculatory tract of the myocardial complex (LV + IVS) in the process of early postnatal ontogenesis of rats Wistar. Visnyk problem biolohiyi i medytsyny. 2022;3(166):104-114. [in Ukrainian].
  6. Chertok VM, Zakharchuk NV, Chertok AG. The cellular and molecular mechanisms of angiogenesis regulation in the brain. Zhurnal Nevrologii I Psikhiatrii imeni S. Korsakova. 2017;117(8):43-55.
  7. Byelichenko VM, Hryhoryeva TA. Novi materialy dlya rozuminnya mekhanizmiv ontohenezu krovonosnoyi systemy teplokrovnykh. Byuleten ZI RAMN. 2004;2(112):114-117. [in Ukrainian].
  8. Amirov DR, Tamimdarov BF. Klinicheskaya gematologiya zhivotnykh. Kazan: Information Technology Centre KGAVM; 2020. 134 s.
  9. Livanova AA, Deev RV. Sovremennyye metody issledovaniya angiogeneza v eksperimente. Genu & Cellis. 2015;X(1):195-221.
  10. Chukhray SM. Ultrastruktura krovonosnykh kapilyariv miokarda yuvenilnykh ta molodykh shchuriv iz vrodzhenym hipotyreozom. Svit medytsyny ta biolohiyi. 2016;1(55):174-178. [in Ukrainian].
  11. Shakhlamov VA. Kapilyary. M.: VEDI; 2007. 288 s.
  12. Abramova ZI. Teoriya apoptozu, autofahiyi ta nekrozu. Kazan: KFUBPF; 2011. 100 s.
  13. Yarilin AA. Apoptoz: pryroda fenomena ta yoho rol normi ta patolohiyi. Aktualni problemy patofiziolohiyi. Mater. konferen.; 2001; Moskva. Moskva: Medytsyna; 2001. s. 13-56.
  14. Fomchenko NV, Voropayev YE. Biolohichni aspekty apoptozu. Problemy zdorovya ta ekolohiyi 2013;2(1):39-45. [in Ukrainian].
  15. Morozova KN. Elektronnaya mikroskopiya v citologicheskih issledovaniyah: metodicheskoe posobie. Novosibirsk: NNIGU; 2013. 85 s.
  16. Hayer H. Elektronna histokhimiya. Moskva: Svit; 1974. 488 s.
  17. Matey VYE. Zyabrovyy epiteliy prisnovodnykh kistkovykh ryb (morfofunktsionalna orhanizatsiya, adaptatsiya, evolyutsiya) [avtoreferat dysertatsii]. Leninhrad: LHU; 1989. 44 s.
  18. Seytbayev KZH, Bazarbayeva ZHM. Histolohichne vyvchennya zyaber ta orhaniv shlunkovo-kyshkovoho traktu sudaka, shcho meshkaye v ozeri Bilikol. Visnyk KazNU. Ekolohichna seriya. 2012;3(35):202-208.

Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 2, 169, 131-144 pages, index UDC 611.661 : 616.127-092.9:31

DOI:

10.29254/2077-4214-2023-2-169-131-144

2023 Issue 2, 169
capillaries diapedesis of erythrocytes endothelium myocardium
29.06.2023
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