Varzhapetian A. S., Shyshkin M. A.

MORPHOMETRIC ASSESSMENT OF WOUND HEALING ACCORDING TO LOCAL TREATMENT MODALITY

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About the author:

Varzhapetian A. S., Shyshkin M. A.

Heading:

DENTISTRY

Type of article:

Scientific article

Annotation:

Odontogenic phlegmons of the maxillofacial region are among the most severe purulent-inflammatory diseases encountered in dental practice and are associated with extensive local tissue destruction. One of the promising approaches to improving treatment outcomes is the optimization of local postoperative wound management through the use of agents capable of simultaneously modulating inflammation and tissue repair. The aim of the study is to perform a comparative morphometric assessment of the wound healing process in postoperative wounds of patients with odontogenic phlegmons of the maxillofacial region depending on the type of local treatment used. The study included 32 patients with odontogenic phlegmons of the maxillofacial region. A total of 96 biopsy specimens obtained during primary surgery and throughout the treatment period were analyzed. Patients were divided into three groups: a control group receiving standard treatment, a group receiving additional local application of a mumiyo-based dental gel, and a comparison group receiving topical Levomekol ointment. Morphometric evaluation was performed using a semi-quantitative scoring system assessing inflammation, vascularization, epithelialization, and fibrosis. An integral reparative index was calculated to characterize overall tissue repair. Statistical analysis was performed using non-parametric methods. No significant intergroup differences in morphometric parameters were observed on postoperative day 3 (p>0.05). By day 7, significantly higher vascularization scores were detected in both the mumiyo and Levomekol groups compared with the control group (p<0.05). On day 21, the highest vascularization and fibrosis scores were observed in the mumiyo group. The reparative index reached 8.0 [7.0; 8.0] points in this group, which was significantly higher than in both the control and Levomekol groups (p<0.001). These findings indicate more intensive granulation tissue formation, neovascularization, and connective tissue remodeling following the use of mumiyo. Local application of a mumiyo-based dental gel promotes accelerated reparative processes in postoperative wounds of patients with odontogenic phlegmons of the maxillofacial region and provides superior morphometric healing outcomes compared with standard treatment alone and topical Levomekol therapy.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 3, 182, 455-461 pages, index UDC 616.716.8-002.3-089:616-003.93:615.454

DOI:

10.29254/2077-4214-2026-3-182-455-461