Nefodova O. O., Yanushkevich K. S.

EXPERIMENTAL STUDY OF THE ISOLATED INFLUENCE OF CADMIUM SALTS ON THE MORPHOLOGY AND BIOCHEMISTRY OF THE LIVER OF RATS

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About the author:

Nefodova O. O., Yanushkevich K. S.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

The development of cadmium-induced hepatocellular injury has many similarities with the formation of Pb-associated hepatotoxicity. Thus, the negative effect of cadmium on the hepatobiliary system is also mediated primarily by the formation of bonds with SH groups of mitochondrial protein molecules and the development of oxidative stress, which causes the depletion of cellular GSH content. In addition, cadmium competes with essential metals (zinc Zn, selenium Se, copper Cu and calcium Ca), displacing them from metal-containing complexes, causing metabolic disorders, inhibiting mitochondrial energy generation and a decrease in the energy potential of cells, affecting DNA repair systems and redox state, and changes intercellular adhesion by inducing the dissociation of the E-cadherin/β-catenin complex. Chronic exposure to cadmium chloride at a dose of 2.0 mg/kg led to changes in the morphological structure of the liver of experimental animals, which was manifested by a significant increase in the thickness of the liver capsule, an increase in the diameter of blood vessels with local haemorrhages in the parenchyma of the organ (on the 30th day of the experiment), an increase in the number of connective tissue elements and parenchymal compaction in the rat experiment. Chronic administration of cadmium chloride to rats leads to a rise in the activity of aspartate aminotransferase and alanine aminotransferase in the blood of male rats compared to the control group at both periods of the study, which was confirmed by the calculation of the De R

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 4, 171, 351-360 pages, index UDC 615.099:[546.48:546.81]:616.36-092.9-07-085.243.3

DOI:

10.29254/2077-4214-2023-4-171-351-360