Nefodova O. O., Shevchenko O. S.

EXPERIMENTAL STUDY OF CADMIUM ACCUMULATION IN THE LOWER JAW OF RATS UNDER CONDITIONS OF CORRECTION WITH ZINC AND IRON SUCCINATE

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About the author:

Nefodova O. O., Shevchenko O. S.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

One of the most dangerous, long-lasting and persistent pollutants is heavy metals, the most typical anthropogenic associations of which are lead Pb, cadmium Cd, nickel Ni, as well as tin Sn, cobalt Co, mercury Hg, antimony Sb and bismuth Bi. Currently, the most common environmental toxicants in the group of heavy metals are mercury, cadmium and lead salts, which, when ingested by mammals, stimulate oxidative stress and compete with biogenic metals (zinc, manganese, copper, iron, calcium, etc.) for binding to the active site of many proteins and enzymes, causing their dysfunction. Accumulating in the body, cadmium has both direct and indirect adverse effects, mainly on the reproductive, endocrine, immune systems, blood, kidneys and bone tissue, causing significant changes in them and inducing degeneration and transmutation of the cellular apparatus. The peculiarities of cadmium accumulation in rat bones under isolated administration and under correction conditions with zinc and ferrous succinates were determined using polyelement analysis of biological materials and objects by atomic emission with electric arc atomisation. Chronic intragastric administration of cadmium chloride at a dose of 2.0 mg/kg leads to a decrease in the zinc level in the mandible's bone tissue compared to the control values both on the 20th and 30th day of the study. Zinc succinate reduces the cadmium level in the mandible's bone tissue with combined intragastric administration in a chronic experiment on rats. During the 30 days of the experimental study, no significant difference in the effect of the studied factors on the calcium level of the mandible was determined.

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Bibliography:

1. U.S. Environmental Protection Agency. Chemicals and Toxics Topics. US EPA. Available from: https://www.epa.gov/environmental-topics/ chemicals-and-toxics-topics.
2. Landrigan PJ, Fuller R, Acosta NJR, Adeyi O, Arnold R, Basu NN, et al. The Lancet Commission on pollution and health. Lancet. 2018;391(10119):462-512. DOI: 10.1016/S0140-6736(17)32345-0.
3. Zhang Q, Hou Q, Huang G, Fan Q. Removal of heavy metals in aquatic environment by graphene oxide composites: a review. Environ Sci Pollut Res Int. 2020;27(1):190-209. DOI: 10.1007/s11356-019-06683-w.
4. Lee WK, Thévenod F. Cell organelles as targets of mammalian cadmium toxicity. Arch Toxicol. 2020;94(4):1017-1049. DOI: 10.1007/ s00204-020-02692-8.
5. Massányi P, Massányi M, Madeddu R, Stawarz R, Lukáč N. Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs. Toxics. 2020;8(4):94. DOI: 10.3390/toxics8040094.
6. Kim JJ, Kim YS, Kumar V. Heavy metal toxicity: An update of chelating therapeutic strategies. J Trace Elem Med Biol. 2019;54:226-231. DOI: 10.1016/j.jtemb.2019.05.003.
7. Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A. Cadmium: Human health and environmental toxicology. Int. Environ. Res. Public Health. 2020;17:679.
8. Unsal V, Dalkıran T, Çiçek M, Kölükçü E. The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review. Adv Pharm Bull. 2020;10(2):184-202. DOI: 10.34172/apb.2020.023.
9. Zhang RK, Wang P, Lu YC, Lang L, Wang L, Lee SC. Cadmium induces cell centrosome amplification via reactive oxygen species as well as endoplasmic reticulum stress pathway. J Cell Physiol. 2019;234(10):18230-18248. DOI: 10.1002/jcp.28455.
10. Watanabe M, Henmi K, Ogawa K, Suzuki T. Cadmium-dependent generation of reactive oxygen species and mitochondrial DNA breaks in photosynthetic and non-photosynthetic strains of Euglena gracilis. Comp Biochem Physiol C Toxicol Pharmacol. 2003;134(2):227-34. DOI: 10.1016/s1532-0456(02)00253-3.
11. He S, Zhuo L, Cao Y, Liu G, Zhao H, Song R, et al. Effect of cadmium on osteoclast differentiation during bone injury in female mice. Environ Toxicol. 2020;35(4):487-494. DOI: 10.1002/tox.22884.
12. Gu J, Li S, Wang G, Zhang X, Yuan Y, Liu X, et al. Cadmium Toxicity on Chondrocytes and the Palliative Effects of 1α, 25-Dihydroxy Vitamin D3 in White Leghorns Chicken’s Embryo. Front Vet Sci. 2021;8:637369. DOI: 10.3389/fvets.2021.637369.
13. García-Mendoza D, Han B, van den Berg HJHJ, van den Brink NW. Cell-specific immune-modulation of cadmium on murine macrophages and mast cell lines in vitro. J Appl Toxicol. 2019;39(7):992-1001. DOI: 10.1002/jat.3788.
14. Rodríguez J, Mandalunis PM. Effect of cadmium on bone tissue in growing animals. Exp Toxicol Pathol. 2016;68(7):391-7. DOI: 10.1016/j. etp.2016. 06.001.
15. Nefodov OO, Bilyshko DV, Kushnarova KA, Shevchenko OS, Shatorna VF, Kefeli-Yanovsʹka OI, et al. Vyznachennya vplyvu kadmiyu na pokaznyky embriohenezu pry izolʹovanomu vvedenni ta v kombinatsiyi z tsytratamy selenu ta hermaniyu. Medychni perspektyvy. 2020;25(1):24-31. [in Ukrainian].
16. Stefanov AV. Doklinichni doslidzhennya likarsʹkykh zasobiv. Kyiv: Avicenna; 2001. 528 s. [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 4, 171, 341-350 pages, index UDC 615.099:[546.48:546.81]:616.36-092.9-07-085.243.3

DOI:

10.29254/2077-4214-2023-4-171-341-350