Lomyha L. L., Kolosova I. I.
EXPERIMENTAL DETERMINATION OF CHANGES IN BIOCHEMICAL BLOOD PARAMETERS OF RATS AS PROGNOSTIC MARKERS FOR THE DEVELOPMENT OF CARDIAC PATHOLOGY UNDER THE INFLUENCE OF CADMIUM CHLORIDE
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About the author:
Lomyha L. L., Kolosova I. I.
Heading:
BIOLOGY
Type of article:
Scientific article
Annotation:
Excessive intake of cadmium into the body exerts a pronounced multi-organ toxic effect, leading to changes in the activity of various enzymes, shifts in fundamental morphological parameters, and a significant disruption of microelement balance. The aim of the study was to identify the patterns of changes in the activity of biochemical marker enzymes in the blood of rats against the background of chronic cadmium intoxication, as well as to evaluate the effectiveness of zinc and copper succinates as potential corrective agents against the cardiotoxic effects of cadmium chloride during simultaneous chronic administration. The experiment was chronic in nature. All pregnant female rats were divided into 4 groups (16 females per group): in addition to the control group, there was a group receiving an isolated solution of cadmium chloride, and two groups receiving combined administration of cadmium with either copper succinate or zinc succinate. The research methodology was based on a comprehensive analysis of biochemical markers of cytolysis and morphometric parameters of the heart. The diagnostic complex included determining the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) in the blood serum of pregnant rats on the 13th and 20th days of the experiment, as well as calculating the heart mass index. Biochemical screening results confirmed the pronounced cardiotoxicity of cadmium chloride. Isolated intoxication was accompanied by a persistent cytolytic effect: ALT activity exceeded control values by 2 times, LDH by 1.9 times, and AST by 1.2 times. Under conditions of combined administration of the toxicant with biogenic metal succinates, a positive trend in the recovery of the blood metabolic profile was established. The data obtained indicate that zinc and copper succinates effectively neutralize destructive changes in the myocardium caused by chronic cadmium exposure, justifying their role as promising agents for metabolic correction.
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Publication of the article:
«Bulletin of problems biology and medicine», 2026 Issue 2, 181, 147-152 pages, index UDC 611.36:616-092:546.46/48’131:546.56:546.56:546.72
