Kotsabyn N. V., Kosharny V. V.

EVALUATION OF HYSTEROSCOPIC AND IMMUNOHISTOCHEMICAL CHANGES IN THE ENDOMETRIUM OF PATIENTS WITH INFERTILITY

---

Show/Download

About the author:

Kotsabyn N. V., Kosharny V. V.

Heading:

PATHOMORPHOLOGY

Type of article:

Scientific article

Annotation:

To date, there are still no clear criteria for establishing the diagnosis of endometritis according to both histological and immunohistochemical studies. There are also no generally accepted diagnostic criteria for the minimum number of plasma cells for establishing the diagnosis of endometritis. The research method was to assess the presence of visible signs of inflammation of endometritis in the yolk sac and infertile women undergoing ART treatment and to trace the correlation of these indicators according to the results of immunohistochemical analysis. It should be noted that immunohistochemical analysis of CD138 is a very accurate method for detecting chronic endometritis. The number of signs is directly correlated with the accuracy of diagnosis: the more signs, the higher the probability of confirming the diagnosis using CD138. When combining several signs of endometritis, in particular, when three or four signs are combined, the accuracy reaches 100% confirmation by immunohistochemical analysis. There is a place for active assessment of visual signs, the absence of immunohistochemical signs with minor signs was only in 64% of responses.

Tags:

Bibliography:

1. Břečka K, Sehnal B, Maxová K, Halaška MJ, Keprtová K, Hruda M, et al. Chronic endometritis – a constantly discussed issue in infertile women. Ceska Gynekol. 2024;89(3):230-236. DOI: 10.48095/cccg2024230.
2. Vitagliano A, Laganà AS, De Ziegler D, Cicinelli R, Santarsiero CM, Buzzaccarini G, et al. Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome-A Systematic Review and Meta-Analysis. Diagnostics (Basel). 2022;12(9):2250. DOI: 10.3390/diagnostics12092250.
3. Cicinelli E, Trojano G, Vitagliano A. Management of chronic endometritis before in vitro fertilization: lights and shadows. Fertil Steril. 2022;118(2):347-348. DOI: 10.1016/j.fertnstert.2022.06.022.
4. Morimune A, Kimura F, Nakamura A, Kitazawa J, Takashima A, Amano T, et al. The effects of chronic endometritis on the pregnancy outcomes. Am J Reprod Immunol. 2021;85(3):e13357. DOI: 10.1111/aji.13357.
5. Osada H, Seto M, Nakase K, Ezoe K, Miyauchi O, Fujita H, et al. Prevalence of chronic endometritis in patients with infertility due to hydrosalpinx or pelvic peritubal adhesions and effect of laparoscopic surgical correction on pregnancy rates post in vitro fertilization. Eur J Obstet Gynecol Reprod Biol. 2023;284:143-149. DOI: 10.1016/j.ejogrb.2023.03.021.
6. Park HJ, Kim YS, Yoon TK, Lee WS. Chronic endometritis and infertility. Clinical and experimental reproductive medicine. 2016;43(4):185- 192. DOI: https://doi.org/10.5653/cerm.2016.43.4.185.
7. Johnston-MacAnanny EB, Hartnett J, Engmann LL, Nulsen JC, Sanders MM, Benadiva CA. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertility and sterility. 2010;93(2):437-441. DOI: https://doi.org/10.1016/j.fertnstert.2008.12.131.
8. Hirata K, Kimura F, Nakamura A, Kitazawa J, Morimune A, Hanada T, et al. Histological diagnostic criterion for chronic endometritis based on the clinical outcome. BMC Womens Health. 2021;21(1):94. DOI: 10.1186/s12905-021-01239-y.
9. Cicinelli E, Vitagliano A, Kumar A, Lasmar RB, Bettocchi S, Haimovich S, et al. Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study. Fertility and sterility. 2019;112(1):162-173.e2. DOI: https://doi.org/10.1016/j.fertnstert.2019.03.004.
10. Mihara M, Yasuo T, Kitaya K. Precision Medicine for Chronic Endometritis: Computer-Aided Diagnosis Using Deep Learning Model. Diagnostics (Basel). 2023;13(5):936. DOI: 10.3390/diagnostics13050936.

Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 469-475 pages, index UDC 618.177:611.018.54:616-089.888

DOI:

10.29254/2077-4214-2025-1-176-469-475