Nekhanevych O. B., Baklanov M. S.

EFFECTIVENESS OF HIGH-INTENSITY INTERVAL TRAINING IN PATIENTS WITH LUNG CANCER

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About the author:

Nekhanevych O. B., Baklanov M. S.

Heading:

PHYSICAL THERAPY AND REHABILITATION

Type of article:

Scientific article

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A few studies indicate the potential effectiveness of rehabilitation programs for patients with nonsmall cell lung cancer (NSCLC), particularly in terms of ventilation, general endurance, functioning, and quality of life. Recent studies have shown the effectiveness of high-intensity exercise training for patients with NSCLC. However, there is no consensus on the content of such training, dosage, criteria for starting and duration of therapy, which requires development and scientific justification. The aim of the study is to increase the effectiveness of physical rehabilitation of patients with NSCLC by developing and validating a program of high-intensity interval therapeutic training on a bicycle ergometer during the post-acute and long-term periods. The study was conducted during 2023–2026. 93 patients with NSCLC were included. After applying the inclusion/ exclusion criteria, 84 people continued to participate in the study. MG patients (58 people) were divided into 2 subgroups (MG 1 and MG 2) using a randomization table, 29 people in each. Starting from the 5th week after surgery, all MG patients were offered a rehabilitation program for 3 months. At the same time, MG 1 included cyclic exercises on a bicycle ergometer of moderate intensity, and MG 2 used high-intensity interval training on a bicycle ergometer. The duration of cycling training in both groups was 45 minutes. MG 1 and MG 2 also were prescribed exercises to develop the strength of the muscles of the limbs and torso, and respiratory exercises. The control group (CG) included 26 patients who refused to perform therapeutic exercises. During the 1st visit and at the end of 3 months (visit 2), all patients underwent a comprehensive examination. Forced expiratory volume in 1 second (FEV1) and vital capacity (VC) were determined, general endurance was determined by the 6-minute walk test (6MWT), quality of life was determined by the EORTC QLQ-C30 (version 3). At the end of the 4th month after surgery, positive dynamics of VC and FEV1 were noted in all observation groups (p<0.05). However, in MG1 and MG2, according to the VC indicator, it was 3.3 times better than in the CG, and according to the FEV1 indicator, it was 1.8 and 2.0 times better in MG1 and MG2, respectively (p<0.05). An increase in the distance of 6MWT was established both in the CG and in MG1 and MG2, in particular, the distance increased by 4.8%, 16.9% and 22.7%, respectively, in groups (p<0.05). In MG2, the increase in distance was statistically significantly better than in MG1 (p<0.05). There were also positive changes in the ability to perform everyday tasks, which determined the dynamics of quality of life indicators according to EORTC QLQ-C30 in MG1 and MG2 patients (p<0.05). Cyclic training on a bicycle ergometer in constant and interval modes in combination with strength and breathing exercises is an effective and safe means for patients with NSCLC to restore indicators of general endurance, ventilatory functions and quality of life. The use of high-intensity interval training has the advantage of restoring overall endurance performance in the post-acute and long-term rehabilitation periods.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 2, 181, 305-309 pages, index UDC 61:615.8:617.54-089.85:616-006.66

DOI:

10.29254/2077-4214-2026-2-181-305-309