Mizin V. V., Severynovska O. V.

CAFFEINE AS A POTENTIAL MODULATOR OF DEPRESSIVE BEHAVIOR IN MALE RATS: COMPARISON OF UNPREDICTABLE AND CONTAGIOUS DEPRESSION

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About the author:

Mizin V. V., Severynovska O. V.

Heading:

BIOLOGY

Type of article:

Scientific article

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One of the leading causes of decreased quality of life in the world is depressive disorders. In this regard, special attention is paid to the study of the modulation of the depressive state and substances capable of providing a stimulating and potentially antidepressant effect. The study aimed to assess the impact of caffeine on depressive-like behavior in models of stress-induced and contagious depression in male rats. The study was conducted on white sexually mature male rats weighing 230–300 grams. Rats were divided into six groups: intact; animals with depression (unpredictable stress method); animals that were administered caffeine via gavage at a concentration of 25 mg/kg for 5 weeks; animals with depression that were administered caffeine; animals with contagious depression; animals with contagious depression that were administered caffeine. Manifestations of a depressive-like state and the effect of caffeine were assessed using the following methods: open field, forced swimming, and sucrose preference test. According to the results of the study, in rats with both models of depression, motor activity was significantly reduced as an indicator of psychomotor inhibition. The immobility time increased, and the climbing time decreased in the forced swimming test, which indicates increased hopelessness and reduced motivation. The consumption of sugar solution decreased, indicating the development of anhedonia. The effect of caffeine on control animals was less pronounced than on animals with depression. In groups with stress-induced and contagious depression, caffeine demonstrated a pronounced stimulating effect, partially restoring motor activity, reduced immobility time, increased climbing time, and significantly increased the consumption of sucrose solution in animals with a depression model to the level of control values. The results obtained indicate a potential corrective antidepressant effect of caffeine.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 105-115 pages, index UDC 612.8:615.214

DOI:

10.29254/2077-4214-2025-1-176-105-115