Kovaltsova M. V., Kucheriavchenko M. O., Huliieva V. K., Buha V. V., Boiko I. S., Sliusarenko D. S., Butko V. V.
BIOCHEMICAL CHANGES IN THE ENDOCRINE PART OF THE PANCREAS UNDER THE EFFECT OF A HYPERCALORIC DIET IN THE EXPERIMENT
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About the author:
Kovaltsova M. V., Kucheriavchenko M. O., Huliieva V. K., Buha V. V., Boiko I. S., Sliusarenko D. S., Butko V. V.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Hypercaloric nutrition of rats negatively affects the functional state of the endocrine part of the pancreas and leads to an imbalance in blood plasma parameters. Malnutrition leads to hyperinsulinemia, while glycemia levels remain elevated, requiring the production of even more insulin by pancreatic β-cells. Gradually, chronic compensatory hyperinsulinemia develops, which is secondary and has an adaptive value for reducing glycemia. The absence of adequate glucose levels for insulin release leads to a shift in the balance between hormones towards counterinsulin factors that stimulate lipolysis, glycolysis, and gluconeogenesis, with the subsequent development of hyperglycemia. High levels of unesterified fatty acids inhibit glycolysis. Ultimately, the metabolism of fatty acids produces ketone bodies, which reflect intracellular glucose deficiency and, under conditions of oxygen deficiency, can damage cell membranes and disconnect oxidation and phosphorylation in the mitochondria of cells. High levels of unesterified fatty acids and glucose have a joint inhibitory effect on the use of each other as an energy source: when unesterified fatty acids are available as energy substrates, their metabolism causes high levels of acetyl-CoA in mitochondrial cells, which leads to impaired use of glucose as an energy source. The established hormonal-substrate relationships due to the consumption of excessive amounts of fats and carbohydrates in the diet of rats reflect pancreatic hyperfunction and associated metabolic disorders, which is a risk factor for the development of functional pancreatic disorders in animals.
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Bibliography:
- Cloete L. Diabetes mellitus: an overview of the types, symptoms, complications and management. Nurs Stand. 2022 Jan 5;37(1):61-66. DOI: 10.7748/ns.2021.e11709.
- Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, et al. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol. 2022 May;199:115015. DOI: 10.1016/j.bcp.2022.115015.
- Darenskaya MA, Kolesnikova LI, Kolesnikov SI. Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bull Exp Biol Med. 2021 May;171(2):179-189. DOI: 10.1007/s10517-021-05191-7.
- Nakamura T, Ichii O, Irie T, Kouguchi H, Sotozaki K, Chihara M, et al. Cotton rat (Sigmodon hispidus) develops metabolic disorders associated with visceral adipose inflammation and fatty pancreas without obesity. Cell Tissue Res. 2019 Feb;375(2):483-492. DOI: 10.1007/s00441-018-2908-9.
- Lees HJ, Swann JR, Poucher S, Holmes E, Wilson ID, Nicholson JK. Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena. J Proteome Res. 2019 May 3;18(5):2160-2174. DOI: 10.1021/acs.jproteome.9b00040.
- Kovaltsova MV, Miroshnychenko MS, Kucheriavchenko MO, Kuznetsova MO, Ohnieva LH, Sypalo AO, et al. Osoblyvosti biokhimichnykh zmin ekzokrynnoi chastyny pidshlunkovoi zalozy pry dii hiperkaloriinoi diiety. Visnyk problem biolohii i medytsyny. 2023;3(170):217-222. DOI: 10.29254/2077-4214-2023-3-170-217-222. [in Ukrainian].
- Ametov AS. Faktory rysku sakharnoho diabeta. Rol ozhyreniia. Endokrinolohiia. 2003;11(27):1477-1486.
Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 179-184 pages, index UDC 616.37:613.863]–092.9–092:612.345
