Ivanytska O. S., Tkachenko P. I., Bilash S. M., Voloshina L. I., Faustova M. O., Yaroshenko I. R., Abdelrazik Haggag

APPLICATION OF IMMUNOSTIMULANTS IN COMBINATION WITH ANTIOXIDANTS IN THE COMPREHENSIVE TREATMENT OF PATIENTS WITH ODONTOGENIC PHLEGMONS

---

Show/Download

About the author:

Ivanytska O. S., Tkachenko P. I., Bilash S. M., Voloshina L. I., Faustova M. O., Yaroshenko I. R., Abdelrazik Haggag

Heading:

DENTISTRY

Type of article:

Scientific article

Annotation:

Purulent-inflammatory diseases of the maxillofacial region occupy a significant place in the clinic of surgical dentistry. The work is devoted to the study of the issue of stabilizing general immunity in odontogenic phlegmons by improving the standard protocol for providing surgical dental care, namely, including immunostimulants in combination with antioxidants in the composition of conservative therapy. Patients with odontogenic phlegmons (50 persons) were divided into 2 groups: the control group, whose treatment was carried out according to the standard protocol, the main group – patients, who were treated according to the protocol with an addition. The conservative treatment additionally included "Filgrastim" and "Cytoflavin". It was revealed that an improvement in the general condition of 22 patients of main group was noted on the 4th day after surgery, in 4 patients – on the 6th day, a decrease in pain syndrome was observed on average on the 5th day. In 19 patients, the absence of purulent exudate was noted on the 4th day, the appearance of granulations on the 6th, and complete epithelialization of the wound on the 7-8th day. The number of peripheral blood erythrocytes during the treatment tended to increase only in patients of the main group – on the 9th day the values approached the normal level and were significantly higher than those of patients of the control group. The level of hemoglobin concentration in the main group of patients also increased slightly. The tendency to normalization of the number of cellular elements in patients of the main group was noted already from the 5th day of the postoperative period. The results of the study demonstrated that the use of a protocol with an addition that includes immunostimulants and antioxidants in the comprehensive treatment of patients with odontogenic phlegmons allows achieving optimal functional and cosmetic results.

Tags:

Bibliography:

1. Malanchuk V, Sidoryako A, Vardzhapetian S. Modern treatment methods of phlegmon in the maxillo-facial area and neck. Georgian Me News. 2019;294:57-61.
2. Avetikov DS, Kuong Vu Vyet, Stavytskiy SO, Lokes KP, Voloshyna LI. Dynamika klinichnykh zmin i zahoiennia hniinykh ran pry zastosuvanni nanokapsul fosfatydylkholinu v kompleksi likuvannia khvorykh iz flehmonamy dna porozhnyny rota. Klinichna Khirurhiia. 2015;3:42- 5. [in Ukrainian].
3. Ferjaoui M, Kolsi N, Bergaoui E, Naouar M, Bouatay R, Harrathi K, et al. Odontogenic cervical-facial cellulitis: report of 87 cases. Revue Medicale de Liege. 2022;77(3):181-186
4. Alotaibi N, Cloutier L, Khaldoun E, Bois E, Chirat M, Salvan D. Criteria for admission of odontogenic infections at high risk of deep neck space infection. European Annals of Otorhinolaryngoly, Head and Neck Diseases. 2015;132(5):261-4. DOI: 10.1016/j.anorl.2015.08.007.
5. Taub D, Yampolsky A, Diecidue R, Gold L. Controversies in the Management of Oral and Maxillofacial Infections. Oral and Maxillofacial Surgery Clinics of North America. 2017;29(4):465-473. DOI: 10.1016/j.coms.2017.06.004.
6. Wang B, Gao BL, Xu GP, Xiang C. Images of deep neck space infection and the clinical significance. Acta Radiol. 2014;55(8):945-51. DOI: 10.1177/0284185113509093.
7. Heim N, Faron A, Wiedemeyer V, Reich R, Martini MJ. Microbiology and antibiotic sensitivity of head and neck space infections of odontogenic origin. Differences in inpatient and outpatient management. Craniomaxillofacial Surgery. 2017;45(10):1731-1735. DOI: 10.1016/j.jcms.2017.07.013.
8. Avetikov DS, Lychman VO, Lokes KP, Steblovsky DV, Bondarenko VV, Shlykova OA, et al. Treatment of odontogenic phlegmons in patients taking into account the biorithm of life. Wiadomosci Lekarskie. 2021;74(6):1346-1348.
9. Tormes AK, De Bortoli MM, Júnior RM, Andrade ES. Management of a Severe Cervicofacial Odontogenic Infection. The Journal of Contemporary Dental Practice. 2018;19(3):352-355.
10. Chumpitaz-Cerrate V, Chávez-Rimache L, Rodriguez-Flores A. Need for randomised clinical trials on antibiotic treatment for odontogenic cervicofacial infections. British Journal of Oral and Maxillofacial Surgery. 2020;58(9):e131-e132. DOI: 10.1016/j.bjoms.2020.06.017.
11. Mahran H, Hassanein AG, Rizq M. Trends and Outcome of Aggressive Fascial Space Infections. Surgical Infections (Larchmt). 2023;24(5):475-481. DOI: 10.1089/sur.2023.079.

Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 500-506 pages, index UDC 616-002.36-085:615.35/.37

DOI:

10.29254/2077-4214-2025-1-176-500-506