Cheliy A. O.

ANALYSIS OF THE EFFECTIVENESS OF THE DEVELOPED TECHNIQUE FOR THE SIMULTANEOUS FORMATION OF A COMBINED FIBRIN- OSSEOUS SCAFFOLD USING THE SINUS LIFT TECHNIQUE

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About the author:

Cheliy A. O.

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DENTISTRY

Type of article:

Scientific article

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The article discusses the main approaches and directions for improving the efficiency of bone augmentation during the sinus lift technique. The study aimed to enhance the efficiency of the sinus lift technique using allo-autologous material obtained by simultaneously centrifuging bone grafting material granules, autologous bone grafting material, and the patient's venous blood. undefinedourcalcenes.com 60 patients aged 20 to 40 years with atrophy of the alveolar process of the upper jaw were selected for clinical trials. All patients were divided into groups I and II, who underwent sinus lift surgery and bone grafting. In group I, a scaffold was used, which was prepared according to the protocol developed by us. Our results of postoperative clinical and radiological studies confirm the effectiveness of the technique developed by us. This effectiveness was confirmed by positive results of sinus lift technique in 28 (93.3%) patients of group I and 15 (62.5%) patients of group II. This was evidenced by a pronounced trabecular pattern of bone tissue, with a density of 639.34 ± 15.14 HU, and a structurally integral formed augmentation, resulting in a significant increase in height from 8 to 12 mm. On the contrary, in group II, the majority of patients had a com pact, formed type of structure in the newly formed bone tissue, with a density of 772.28 ± 17.36 HU, in combination with a structurally unformed granular pattern, characterised by a parietal distribution of the material. Based on our studies, we have determined that the stable combined fibrin scaffold we have developed exhibits a pronounced osteoconductive and osteoinductive effect, which is reflected in the complete restoration of bone tissue over the entire area of augmentation.

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1. Kim BJ, Kwon TK, Baek HS, Hwang DS, Kim CH, Chung IK, et al. A comparative study of the effectiveness of sinus bone grafting with re combinant human bone morphogenetic protein 2-coated tricalcium phosphate and platelet-rich fibrin-mixed tricalcium phosphate in rabbits. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(5):583-92. DOI: 10.1016/j.tripleo.2011.04.029.
2.  Amam MA, Abdo A, Alnour A, Amam A, Jaafo MH. Comparison of calcium sulfate and tricalcium phosphate in bone grafting after sinus lifting for dental implantation: A randomized controlled trial. Dent Med Probl. 2023;60(2):239-246. DOI: 10.17219/dmp/151983.
3.  Okada T, Kanai T, Tachikawa N, Munakata M, Kasugai S. Long-term radiographic assessment of maxillary sinus floor augmentation using beta-tricalcium phosphate: Analysis by cone-beam computed tomography. Int J Implant Dent. 2016;2(1):8. DOI: 10.1186/s40729-016-0042-6.
4. Oba Y, Tachikawa N, Munakata M, Okada T, Kasugai S. Evaluation of maxillary sinus floor augmentation with the crestal approach and beta-tricalcium phosphate: A cone-beam computed tomography 3- to 9-year follow-up. Int J Implant Dent. 2020;6(1):27. DOI: 10.1186/s40729-020-00225-7.
5.  Avetikov DS, Stavytskyi SA, Lokes KP, Yatsenko IV. Otsinka efektyvnosti auhmentatsii alveoliarnoho hrebnia na etapi pidhotovky do dentalnoi implantatsii. Visnyk problem biolohii i medytsyny. 2016;1(131):240-2. [in Ukrainian].
6. Pavlenko AV, Dmitrieva EA, Luzin VI. Histolohicheskoye stroeniye regenerata pri zapolnenii kostnogo defekta materialami Easygraft i trikaltsiyfosfatom. Morfologiya. 2011;5(2):49-54. [in Ukrainian].
7.  Pavlenko OV, Dmytriieva YeO. Morfolohichni osnovy vyboru kistkovoplastychnykh materialiv u parodontolohii. Morfolohiia. 2011;5(1):5-12. [in Ukrainian].
8.  Berwig KH, Baldasso C, Dettmer A. Production and characterization of poly(3-hydroxybutyrate) generated by Alcaligenes latus using lactose and whey after acid protein precipitation process. Bioresour Technol. 2016;218:31-7.
9.  Hapach LA, Vander Burgh JA, Miller JP, Reinhart-King CA. Manipulation of in vitro collagen matrix architecture for scaffolds of improved physiological relevance. Physical Biology. 2015;12(6):061002. DOI: 10.1088/1478-3975/12/6/061002.
10.  Pantus AV, Rozhko MM, Paliychuk VI, Kovalchuk NY, Melnyk NS. Microstructure of biopolymer micro-fibrous scaffold and its influence on the ability to retain medicines and tissue regeneration. Georgian medical news. 2023;3(336):37-44.
11.  Crisci A, Lombardi D, Serra E, Lombardi G, Cardillo F, Crisci M. Standardized protocol proposed for clinical use of L-PRF and the use of L-PRF Wound Box®. J Unexplored Med Data. 2017;2:77-87. DOI: 10.20517/2572-8180.2017.17.
12.  Kubesch A, Barbeck M, Al-Maawi S, Orlowska A, Booms P, Sader R, et al. A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: An experimental study in vivo. Platelets. 2019;30(3):329-340. DOI: 10.1080/09537104.2018.1445835.
13.  Lee HM, Shen EC, Shen JT, Fu E, Chiu HC, Hsia YJ. Tensile strength, growth factor content and proliferation activities for two platelet concentrates of platelet-rich fibrin and concentrated growth factor. J. Dent. Sci. 2020;15(2):141-146. DOI: 10.1016/j.jds.2020.03.011.
14.  Li W, Sigley J, Pieters M, Helms C, Nagaswami C, Weisel JW, et al. Fibrin Fiber Stiffness Is Strongly Affected by Fiber Diameter, but Not by Fibrinogen Glycation. Biophys. J. 2016;110(6):1400-1410. DOI: 10.1016/j.bpj.2016.02.021.
15.  McLellan J, Plevin S. Temporal release of growth factors from platelet- rich fibrin (PRF) and platelet-rich plasma (PRP) in the horse: a comparative in vitro analysis. International Journal of Applied Research in Veterinary Medicine. 2014;12(1):48-57.
16.  Caymaz G, Uyanik O. Comparison of the effect of advanced platelet-rich fibrin and leukocyte- and platelet-rich fibrin on outcomes after removal of impacted mandibular third molar: A randomized split-mouth study. Niger. J. Clin. Pract. 2019;22(4):546-552. DOI: 10.4103/njcp.njcp_473_18.
17.  Canellas JVDS, Medeiros PJD, Figueredo CMDS, Fischer RG, Ritto FG. Platelet-richfibrin in oral surgical procedures: A systematic review and meta-analysis. Int. J. Oral Maxillofac. Surg. 2019;48(3):395-414. DOI: 10.1016/j.ijom.2018.07.007.
18.  Caruana A, Savina D, Macedo JP, Soares SC. From Platelet- Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery. Eur. J. Dent. 2019;13(2):280-286. DOI: 10.1055/s-0039-1696585.
19.  Crisci A, Manfredi S, Crisci M. Fibrinrich in Leukocyte- Platelets (L-PRF) and Injectable Fibrin Rich Platelets (I-PRF), two opportunity in regenerative surgery: Review of the sciences and literature. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2019;18:66-79.
20.  Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: The first introduction to the low speed centrifugation concept. Eur. J. Trauma Emerg. Surg. 2018;44(1):87-95. DOI: 10.1007/s00068-017-0767-9.
21.  Siawasch SAM, Andrade C, Castro AB, Teughels W, Temmerman A, Quirynen AB. Impact of local and systemic antimicrobials on leuko cyte- and platelet rich fibrin: an in vitro study. Sci Rep. 2022;12:2710. DOI: 10.1038/s41598-022-06473-4.
22.  Crisci A, Barillaro MC, Lepore G, Cardillo F. L-PRF Membrane (FibrinRich in Platelets and Leukocytes) and Its Derivatives (A-PRF, i- PRF) are Help ful as a Basis of Stem Cells in Regenerative Injury Treatment: Trial Work on the Horse. International Blood Research & Reviews. 2019;3(1):1-4.
23.  Crisci A, Benincasa G, Crisci M, Crisci F. Leukocyte Platelet-Rich Fibrin (L-PRF), a new biomembrane useful in tissue repair: basic science and literature review. Biointerface Research in Applied Chemistry. 2018;8(5):3635-43.
24.  De Almeida NCPM, Dos Santos NBM, Completo AMG, De Oliveira FGV. Tensile strength assay comparing the resistance between two different autologous platelet concentrates (leucocyte-platelet rich fibrin versus advanced- plateletrichfibrin): A pilotstudy. Int. J. Implant Dent. 2021;15;7(1):1. DOI: 10.1186/s40729-020-00284-w.
25.  El Bagdadi K, Kubesch A, Yu X, Al-Maawi S, Orlowska A, Dias A, et al. Reduction of relative centrifugal forces increases growth factor release within solid platelet- rich fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). European Journal of Trauma and Emergency Surgery. 2019;45(3):467-79.
26.  Humeniuk RА. Zasoby dlia optymizatsii osteohenezu v stomatolohii: oblast zastosuvannia, aktualnist problemy i perspektyvy rozrobok i vprovadzhennia novykh preparativ. Kyiv; 2021. 152 s. [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 564-576 pages, index UDC 616-071+616,314-007+616.716

DOI:

10.29254/2077-4214-2025-2-177-564-576