Havryliev V. M., Avetikov D. S., Pronina O. M., Skikevych M. G., Yatsenko I. V., Bukhanchenko O. P.

THE ROLE OF IMMUNOGRAM IN THE DIAGNOSTICS OF CHRONIC SIALOADENITIS AND TUMORS OF THE SALIVARY GLANDS

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About the author:

Havryliev V. M., Avetikov D. S., Pronina O. M., Skikevych M. G., Yatsenko I. V., Bukhanchenko O. P.

Heading:

DENTISTRY

Type of article:

Scientific article

Annotation:

Despite the rapid development of medical science, clinicians and scientists do not note a decrease in the number of patients with salivary gland diseases of various genesis. It is believed that the main site of IgA synthesis, up to 30- 35% of the total amount, is the small salivary glands, which provide local immunity in the oral cavity. The purpose of the study is to determine the role of immunological parameters of oral fluid and blood serum in objectifying the state of salivary gland reactivity in patients with chronic sialoadenitis. Oral fluid and blood serum were studied in 32 patients with salivary gland diseases who were on outpatient treatment in the surgical department of the Municipal Enterprise Poltava Regional Center of Dentistry – Dental Clinical Polyclinic of Poltava Regional Council. The studies conducted against the background of exacerbation of clinical manifestations of chronic sialoadenitis and adenomas revealed specific changes in the immunological parameters of patients of all groups (xerostomia with edema in the projection of all major salivary glands, unilateral sialoadenitis, bilateral sialoadenitis of the parotid glands, pleomorphic adenoma of the major salivary glands) compared with similar parameters in the control group. Therefore, certain statistically significant differences in the content of IgM and IgG in the blood serum can be noted, especially in relation to xerostomia. At the same time, the content of IgA did not undergo significant changes in the blood serum, which was characteristic of all these diseases of the salivary glands. This situation is a predictor of the pathological circle: sialodochospasm is caused, which leads to a decrease in the outflow of secretions from the salivary glands, xerostomia, activation of pathogenic microflora, which ascends through the mouth into their ductal system, causing a sluggish course of inflammation in the glands with their simultaneous edema.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 470-475 pages, index UDC 616.316-006-071

DOI:

10.29254/2077-4214-2024-1-172-470-475