Mykhalevych M. M., Podolyuk M. V., Kyryk Kh. A.

THE EFFECT OF TWO- AND THREE-WEEK OPIOID ADMINISTRATION ON THE STRUCTURAL ORGANIZATION OF THE SUBMANDIBULAR GLAND IN AN EXPERIMENT

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About the author:

Mykhalevych M. M., Podolyuk M. V., Kyryk Kh. A.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

This study is dedicatedted to the identification and description of structural changes in the mandibular gland of rats after two and three weeks of opioid administration. The widespread use of opioids and the rapid growth in the number of drug addicts, together with significant economic, social, and moral difficulties, make the problem of drug addiction one of the most pressing in most countries of the world. These circumstances confirm the relevance of further study of the effects of opioids on the human body. The aim is to identify structural changes in the submandibular gland after two and three weeks of opioid exposure and to assess the relationship between the duration of opioid administration and the level of organ destruction. The study used a method of modeling the effect of opioids on the body of white rats and a histological method to study the microstructure of the submandibular gland of rats under the influence of opioids. The first signs of structural changes in the submandibular gland were detected after 2 weeks of intramuscular administration of the opioid (nalbuphine) at a dose of 8 mg/kg in the first week and 15 mg/kg in the second week. Capillary stasis was noted, and edema of the interlobular connective tissue was observed. After three weeks of ad- ministration of an opioid analgesic at a dose of 8 mg/kg in the first week, 15 mg/kg in the second week, and 20 mg/ kg in the third week in the submandibular gland preparations of white rats, an increase in destructive changes in serocytes was observed, in particular the development of necrosis of secretory cells in the terminal protein and mixed sections. Alterative processes were noted in the parenchymal elements of the organ and the further development of discirculatory changes, namely, further dilatation of arterioles and venules, mainly due to their overflow with erythrocytes. Already after 2 weeks of intramuscular administration of the opioid, the first changes in the structure of the submandibular gland are detected. There is a clear relationship between the depth of structural changes in the submandibular gland of the white rat, including its hemomicrocirculatory bed, and the duration of administration of an opioid analgesic.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 395-403 pages, index UDC 611.316-018-06:615.212.7]-092.9

DOI:

10.29254/2077-4214-2025-3-178-395-403