Gorodnytska I. M., Skrypnyk I. M., Maslova G. S.

THE EFFECT OF COMPLEX TREATMENT WITH THE USE OF A CYTOPROTECTOR OF PLANT ORIGIN ON THE INDICATORS OF THE NITRIC OXIDE SYSTEM AND CONNECTIVE TISSUE METABOLISM IN YOUNG PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE WITH HELICOBACTER PYLORI-UNASSOCIATED STATUS

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About the author:

Gorodnytska I. M., Skrypnyk I. M., Maslova G. S.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Gastroesophageal reflux disease (GERD) is increasingly recognized as a significant health problem among young patients. This condition, manifested by the reflux of gastric contents into the esophagus, can cause several symptoms, including heartburn, belching, and difficulty swallowing. This study is devoted to studying the effect of complex therapy with a proton pump inhibitor (pantoprazole) and a complex of plant extracts and salts (dietary supplement "Gastrotop") on the nitric oxide (NO) system and connective tissue metabolism in young people suffering from GERD. The article presents results that confirm that the combination of PPI (pantoprazole) and "Gastrotop" represents a promising strategy for the treatment of GERD, aimed at both the inflammatory and structural components of the disease by regulating the activity of NO synthase isoforms and restoring the protective mechanisms of the esophageal mucosa, correcting the levels of sialic acids and glycosaminoglycans (GAGs). The study involved 30 young patients with GERD, who were divided into two groups: Group I (n=15) – patients with erosive GERD and Group II (n=15) – with non-erosive form. The comparison group consisted of 15 practically healthy individuals. The study of blood plasma before treatment demonstrated a significant increase in the activity of total NO-synthase due to the pro-inflammatory – inducible isoform in the blood serum of patients with both erosive and non-erosive forms of GERD. In addition, an increase in the concentration of GAG and sialic acids was recorded in both groups of patients, which may indicate long-term damage to the mucosa regardless of changes in the endoscopic picture. After treatment with pantoprazole and taking the dietary supplement "Gastrotop" for 30 days, a statistically significant decrease in the activity of both iNOS and the concentration of sialic acids and GAG was recorded, indicating the restoration of barrier function and healing of defects in the esophageal mucosa.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 183-194 pages, index UDC 616.33-008: 615.24-085-053.81

DOI:

10.29254/2077-4214-2025-1-176-183-194