Hnatyuk M. S., Chernetsky A. A., Stets N. Ya., Tatarchuk L. V.

QUANTITATIVE MORPHOLOGICAL ASPECTS OF THE STUDY OF THYROID GLAND STRUCTURES IN WHITE RATS UNDER THE CONDITIONS OF LONG-TERM POSTRESECTION PORTAL HYPERTENSION

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About the author:

Hnatyuk M. S., Chernetsky A. A., Stets N. Ya., Tatarchuk L. V.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

The thyroid gland is an endocrine organ with an intensive blood supply and high metabolism, which is quite sensitive to various negative endo- and exogenous factors and hemodynamic disturbances, which can lead to changes in its structure and function. The aim of the study is morphometrically study the features of structural changes in rat thyroid thyrocytes under conditions of simulated postoperative portal hypertension. The structures of the thyroid gland of three groups of white male Wistar rats were studied using a complex of morphological methods. The first group included 15 control animals after laparotomy, the second group included 34 white male rats with postoperative hypertension in the hepatic portal vein system, and the third group included 15 animals with postresection portal hypertension complicated by multiple organ failure. Postresection portal hypertension was modeled by resection of the left and right lateral lobes of the liver. One month after the start of the experiment, the animals were euthanized by bleeding under anesthesia. Histological micropreparations were prepared from the thyroid gland and examined optically and morphometrically. It was established that in conditions of prolonged postresection portal hypertension, the percentages of small and medium follicles decreased and the percentage of large follicles increased from (14.20±0.12)% to (51.80±0.36)%. It was also established that prolonged postresection portal hypertension resulted in a pronounced structural reorganization of follicular thyrocytes, which was characterized by a decrease in the size of thyrocytes, their nuclei, nuclear-cytoplasmic indices, and an increase in the volume of damaged thyrocytes. The most pronounced structural changes in thyrocytes were found in large follicles with the development of multiple organ failure against the background of postresection portal hypertension.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 2, 181, 243-247 pages, index UDC 616.36-089.87-06.616-91]-092.9

DOI:

10.29254/2077-4214-2026-2-181-243-247