Lavrenko A. V.

PLATELET-RICH PLASMA: CURRENT UNDERSTANDING OF EFFICACY AND THERAPEUTIC APPLICATIONS

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About the author:

Lavrenko A. V.

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PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

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Scientific article

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The text discusses the advantages of autologous platelet concentrates, including their ease of collection and preparation, as well as their safe clinical application without the risks associated with allogeneic products. It describes the areas of use for various types of platelet concentrates in regenerative and sports medicine, dentistry, maxillofacial surgery, and wound treatment. Their classification is presented based on the presence of leukocytes and the characteristics of fibrin architecture (P-PRP, L-PRP, P-PRF, L-PRF), and significant differences in the quantity and dynamics of growth factor release are highlighted. The paper emphasizes the role of platelets in the initial phase of wound healing and the potential for prolonged release of growth factors from high-density fibrin matrices. It is noted that the diversity of preparation protocols complicates the interpretation of clinical outcomes. A comparative in vitro study of L-PRF and L-PRP with natural thrombus allows for a better understanding of their biological properties and potential clinical effects.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 48-50 pages, index UDC 615.382-052:616-08

DOI:

10.29254/2523-4110-2025-4-179/addition-48-50