Chupashko O. I., Kovalchuk S. M., Terletskyj I. R.

MODERN ASPECTS OF INTEGRATIVE PHYSIOLOGY OF INTERMITTENT HYPOXIC TRAINING AS A FACTOR IN ENHANCING THE BODY’S ADAPTIVE CAPACITY

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About the author:

Chupashko O. I., Kovalchuk S. M., Terletskyj I. R.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

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This analytical review elucidates the fundamental role of oxidative metabolism as a non-specific basis for the body’s adaptive capacity and evaluates intermittent hypoxic training (IHT) as an effective non-pharmacological strategy to enhance overall resistance. The paper addresses hypoxia as a universal pathogenic link in acute conditions and chronic degenerative processes characterized by energy deficiency and mitochondrial dysfunction. Based on a systemic analysis of domestic and international publications indexed in PubMed, Web of Science, and Google Scholar databases up to 2025–2026, the scientific legacy of Professor Mykhailo Tymochko and his school is comprehensively summarized. The review analyzes the outcomes of IHT application across various experimental models, including endocrine disorders (hypothyroidism), radiation injury, and chemical intoxications induced by fluoride, alcohol, and nitrites. The scientific legacy of Professor M. Tymochko and his school is summarized in the context of IHT application in experimental models of endocrine disorders (hypothyroidism), radiation damage, and chemical intoxications (fluoride, alcohol, nitrite). The material is supplemented with modern data on the molecular mechanisms of adaptation, including the regulation of the HIF-1α factor, mitochondrial biogenesis, mitophagy processes, and the phenomenon of mitochondrial hormesis. IHT is substantiated as a proactive non-pharmacological strategy for increasing the fundamental resistance of the organism. The review concludes that the universal therapeutic effects of IHT justify a paradigm shift in modern medicine from reactive symptom management towards the proactive fortification of the cellular bioenergetic matrix. Prospects emphasize the translational clinical potential of IHT, alongside its application in sports and environmental medicine, geriatrics to mitigate aging processes, and management of neurodegenerative disease.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 3, 182, 145-149 pages, index UDC 619:612.014.464:612.017

DOI:

10.29254/2077-4214-2026-3-182-145-149