IMPAIRED MOTOR FUNCTION OF THE UPPER DIGESTIVE TRACT IN GASTROESOPHAGEAL REFLUX DISEASE IN CHILDREN

Prokhorova M. P., Karulina Y. V.

IMPAIRED MOTOR FUNCTION OF THE UPPER DIGESTIVE TRACT IN GASTROESOPHAGEAL REFLUX DISEASE IN CHILDREN


Show/Download

About the author:

Prokhorova M. P., Karulina Y. V.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

The significant prevalence of gastroesophageal reflux disease (GERD) among children determines the relevance of this problem. The disease significantly affects the quality of life of patients in the long term, which gives it medical and social significance. Insufficient clarity of issues related to the frequency of cases, clinical manifestations, diagnosis and treatment of GERD in children often causes a delay in diagnosis and deterioration of the quality of life of patients. Based on the analysis of literature sources, summarize the latest achievements in research on the motor function of the upper digestive tract in gastroesophageal reflux disease in children and determine promising directions for its diagnosis and treatment. The features of the clinical course of motor function disorders of the upper digestive tract in gastroesophageal reflux disease in children were studied. Information search and analysis of scientific sources were conducted using the scientometric database PubMed for the last 10 years. Based on a comprehensive clinical, laboratory and instrumental examination of patients with suspected GERD, an obligatory stage is esophagogastroduodenoscopy (EGD) and testing for the presence of H. pylori. If no visible changes in the mucous membrane are detected, and the test result for H. pylori is negative, the patient is classified as having functional dyspepsia (FD). In case of a positive test result, eradication therapy is prescribed. If after eradication dyspeptic symptoms disappear and are not recorded for 6–12 months, dyspepsia associated with H. pylori infection is diagnosed. If dyspeptic symptoms persist or return after treatment, such a patient is also classified as a patient with functional dyspepsia. The questions regarding the actual prevalence of upper gastrointestinal motility disorders, risk factors for their occurrence, and the nature of these disorders in GERD in children remain insufficiently studied and require further scientific research.

Tags:

children, gastroesophageal reflux disease, motor function

Bibliography:

  1. Volosovets OP, Кryuchko TO, Marushko YuV, Shadrin OН, Volosovets TM Pathomorphosis of diseases of the digestive system allergic and non-allergic genesis in children of Ukraine in the dynamics of 25 years of observation. World of Medicine аnd Biology. 2022;3(81):40-45. DOI: https://doi.org/10.26724/2079-8334-2022-3-81-40-45
  2. MOZ Ukrainy. Zakon № 1179 Pro zatverdzhennia Standartu medychnoi dopomohy Hastroezofahealna refliuksna khvoroba u ditei. Kyiv: MOZ Ukrainy; 2023. Dostupno: https://moz.gov.ua/uk/decrees/nakaz-moz-ukraini-vid-29062023--1179-pro-zatverdzhennja-standartu-medichnoi- dopomogi-gastroezofagealna-refljuksna-hvoroba-u-ditej [in Ukrainian].
  3. Beketova H, Moshchych О, Pogorielova K, Kobylynska L. Retrospective Analysis of the Frequency and Characteristics of Gastroesophageal Reflux Disease in Children for 20 Years. Child`s Health. 2025;20:107-116. DOI: https://doi.org/10.22141/2224-0551.20.2.2025.1800
  4. Bielka K, Kuchyn I, Horoshko V. Intensive care units during the Ukraine war: challenges and opportunities. Intensive Care Med. 2023;49(8):1011-1014. DOI: https://doi.org/10.1007/s00134-023-07117-5.22
  5. Volosovets OP, Vyhovska OV, Kryvopustov SP, Mozyrska OV, Yemets OV, Volosovets AO, et al. Problems of providing medical care to children of Ukraine as a result of russian aggression. Child`s Health. 2023;18(3):9-13. DOI: https://doi.org/10.22141/2224-0551.18.3.2023.1578
  6. Volosovets OP, Kryvopustov SP, Kuzmenko AYa, Prokhorova MP, Cherniy OF, Khomenko VE, et al. Changes in the health of children under 1 year of age against the backdrop of war and the COVID-19 pandemic in Ukraine. Zdorovʹe dytyny. 2024;19(6):337-347. DOI: https://doi.org/10.22141/2224-0551.19.6.2024.1737
  7. Sliusar NA, Saltanova SD. The clinical course of functional gastrointestinal disorders accompanied by abdominal pain in children in martial law. Bulletin of problems biology and medicine. 2024;3(174):374-385. DOI: https://doi.org/10.29254/2077-4214-2024-3-174-374-385
  8. Slyusar NA, Kryvopustov SP. The role of serotonin and melatonin in the formation of clinical manifestations of functional gastrointestinal disorders accompanied by abdominal pain in children under martial law. Child`s Health. 2025;20(4):247-253 DOI: https://doi.org/10.22141/2224-0551.20.4.2025
  9. Volosovets OP, Kryvopustov SP, Kuzmenko AYa, Chernyshova OYe, Zabudska LR, Volosovets TM, et al. The impact of breastfeeding on the health of children in Ukraine in conditions of war and the consequences of the COVID-19 pandemic. Eastern Ukrainian Medical Journal. 2025;13(4):1087-1098. DOI: https://doi.org/10.21272/eumj.2025;13(4):1087-1098
  10. Marushko YV, Marushko TV, Dmytryshyn OA, Iovitsa TV, Bovkun OA. Gastrointestinal disorders in secondary lactase deficiency: diagnostic features, correction methods. Modern Pediatrics. Ukraine. 2024;4(140):64-72. DOI: https://doi.org/10.15574/SP.2024.140.64
  11. Mityuryayeva-Korniyko IO, Volosovets, OP, Kryvopustov SP, Burlaka IA, Polukhina MO, Shevchenko TA, et al. Epidemiological assessment of diabetes mellitus in children of Ukraine during the last 20 years (2002-2021) of peacetime. SAGE Open Med. 2024;12:20503121241255213. DOI: https://doi.org/10.1177/20503121241255213
  12. Shadrin OG, Ignatko LV. Modern approaches to the diagnosis and treatment of gastroesophageal reflux disease in children. Zdorovja Ukrainy. Gastroenterologija, gepatologija, koloproktologija. 2016;41:26-27.
  13. Belousova O, Slobodianiuk O, Pavlenko N. Clinical charac-teristics of school-aged children with esophagus diseases. ScienceRise: Medical Science. 2018;23:39-43. DOI: https://doi.org/10.15587/2519-4798.2018.128014.29
  14. Nyankovskyy SL, Horodylovska MI. Prognosis criteria of gas-troesophageal reflux disease treatment efficacy in school-age children. Zdorove rebenka. 2018;13(5):444-449. DOI: https://doi.org/10.22141/2224-0551.13.5.2018.141557.30
  15. Lychkovska O, Semen M, Kulachkovska I, Semen V. Functional Gastrointestinal Disorders in Early Childhood: The Importance of Early Intervention and a Multidisciplinary Approach. Child`s Health. 2025;20(7):520-526. DOI: https://doi.org/10.22141/2224-0551.20.7.2025.1918
  16. Kryuchko TO, Nesina IM, Poda ОА, Bubyr LM. Modern strategy for management of pediatric patients with gastroesophageal reflux disease in compliance with the international and national guidelines. Modern gastroenterology. 2023;6(134):75-85. DOI: http://doi.org/10.30978/MG-2023-6-75
  17. Kryuchko TO, Nesina IM, Tkachenko OYa. Diagnostic algorithm and peculiarities of monitoring for infants with disorders of the gastrointestinal tract. Wiadomości Lekarskie. 2017;LXX(2):275-81.
  18. Azer SA, Goosenberg E. Gastroesophageal reflux disease (GERD). StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554462/
  19. Zheng Z, Shang Y, Wang N. Current advancement on the dynamic mechanism of gastroesophageal reflux disease. Int J Biol Sci. 2021;17(15):4154-4164. DOI: http://doi.org/10.7150/ijbs.65066
  20. Kesavelu D, Franklin N, Venkatraghavan C, Narayan D, Ravindra PK, Wasim A. Prevalence and severity of gastroesophageal reflux disease in Indian children presenting with symptoms of acid reflux: a real-world evidence study. Turk Arch Pediatr. 2025;60(3):341-343. DOI: http://doi.org/10.5152/TurkArchPediatr.2025.24140
  21. Sandipan S, Sudipta M. Pediatric obesity and non-hepatobiliary gastrointestinal disorders: a comprehensive review. Gastroint Hepatol Dig Dis. 2024;7(4):1-8.11. Sintusek P, Mutalib M, Thapar N. Gastroesophageal reflux disease in children: what’s new right now? World J Gastrointest Endosc. 2023;15(3):84-102. DOI: http://doi.org/10.4253/wjge.v15.i3.84
  22. Puri NB, Sanchez R. Gastroesophageal reflux in children. Curr Treat Options Peds. 2025;11:10. DOI: http://doi.org/10.1007/s40746-024-00321-5
  23. McLoughlin VZY, Suaini NHA, Siah K, Loo EXL, Pang WW, Chong YS, et al. Prevalence, risk factors and parental perceptions of gastroesophageal reflux disease in Asian infants in Singapore. Ann Acad Med Singap. 2022;51:263-271. DOI: http://doi.org/10.47102/annals-acadmedsg.2021411
  24. Francis D, Chawla A, LaComb JF, et al. Gastroesophageal reflux and PPI exposure alter gut microbiota in very young infants. Front Pediatr. 2023;11:1254329. DOI: http://doi.org/10.3389/fped.2023.1254329
  25. Vandenplas Y, Orsi M, Benninga M, Gatcheco F, Rosen R, Thomson M. Infant gastroesophageal reflux disease management consensus. Acta Paediatr. 2024;113:403-410. DOI: http://doi.org/10.1111/apa.17074
  26. Visnes ES, Hallan A, Bomme M, Holmberg D, Møller-Hansen J, Lagergren J, et al. Prevalence and risk factors of gastro-oesophageal reflux symptoms among adolescents, the HUNT study. Scand J Gastroenterol. 2024;59(7):816-820. DOI: http://doi.org/10.1080/00365521.2024.2349646
  27. Fernández-González SM, Moreno-Álvarez A, Solar-Boga A. Proton pump inhibitors in pediatric gastroesophageal reflux disease: a systematic review of randomized controlled trials. Children (Basel). 2024;11(3):296. DOI: http://doi.org/10.3390/children11030296
  28. Sadafi S, Azizi A, Pasdar Y, Shakiba E, Darbandi M. Risk factors for gastroesophageal reflux disease: a population-based study. BMC Gastroenterol. 2024;24(1):64. DOI: http://doi.org/10.1186/s12876-024-03143-9
  29. Yu C, Wang T, Gao Y, Jiao Y, Jiang H, Bian Y, at al. Association between physical activity and risk of gastroesophageal reflux disease: a systematic review and meta-analysis. J Sport Health Sci. 2024;13(5):687-698. DOI: http://doi.org/10.1016/j.jshs.2024.03.007
  30. Xie M, Deng L, Fass R, Song G. Obesity is associated with higher prevalence of gastroesophageal reflux disease and reflux related complications: a global healthcare database study. Neurogastroenterol Motil. 2024;36(4):e14750. DOI: http://doi.org/10.1111/nmo.14750
  31. Andrasdi Z, Müller KE, Gaál Z, Nemes É, Felszeghy E. Health related quality of life is associated with gastroesophageal reflux symptoms in overweight children. J Pediatr Endocrinol Metab. 2024;37(1):27-32. DOI: http://doi.org/10.1515/jpem-2023-0315
  32. Zhang M, Hou ZK, Huang ZB, Chen XL, Liu FB. Dietary and lifestyle factors related to gastroesophageal reflux disease: a systematic review. Ther Clin Risk Manag. 2021;17:305-323. DOI: http://doi.org/10.2147/TCRM.S296680
  33. He Y, Duan ZJ, Wang CF, Wei YS, Cai MX. Metabolic dysfunction-associated fatty liver disease increases the risk of gastroesophageal reflux symptoms. Diabetes Metab Syndr Obes. 2022;15:199-207. DOI: http://doi.org/10.2147/DMSO.S339428
  34. Didenko V, Yagmur V, Melanych S, Demeshkina L, Simonova O. Lifestyle modification in the treatment of refractory gastroesophageal reflux disease and non-alcoholic fatty liver disease. A clinical case. Gastroenterologia. 2023;56(4):252-257. DOI: http://doi.org/10.22141/2308-2097.56.4.2022.517
  35. Wang Z, Zhou H, Zhang S, Wang F, Huang H. The causal relationship between COVID-19 and seventeen common digestive diseases: a two-sample, multivariable Mendelian randomization study. Hum Genomics. 2023;17(1):87. DOI: http://doi.org/10.1186/s40246-023-00536-x
  36. He M, Wang Q, Yao D, Li J, Bai G. Association between psychosocial disorders and gastroesophageal reflux disease: a systematic review and meta-analysis. J Neurogastroenterol Motil. 2022;28(2):212-221. DOI: http://doi.org/10.5056/jnm21044
  37. Zamani M, Alizadeh-Tabari S, Chan WW, Talley NJ. Association between anxiety/depression and gastroesophageal reflux: a systematic review and meta-analysis. Am J Gastroenterol. 2023;118(12):2133-2143. DOI: http://doi.org/10.14309/ajg.0000000000002411
  38. Galler A, Thönnes A, Joas J. Clinical characteristics and outcomes of children, adolescents and young adults with overweight or obesity and mental health disorders. Int J Obes. 2024;48:423-432. DOI: http://doi.org/10.1038/s41366-023-01449-4
  39. Shaqran TM, Ismaeel MM, Alnuaman A. Epidemiology, causes, and management of gastro-esophageal reflux disease: a systematic review. Cureus. 2023;15(10):e47420. DOI: http://doi.org/10.7759/cureus.47420
  40. Shahnaz F, Wicaksono YS, Rahman HA. Pediatric gastroesophageal reflux disease (GERD): a literature review. Arch Pediatr Gastroenterol Hepatol Nutr. 2023;2(2):46-60. DOI: http://doi.org/10.58427/apghn.2.2.2023.46-60
  41. Rosen RD, Winters R. Physiology, lower esophageal sphincter Treasure Island (FL): StatPearls Publishing; 2025. Available from: https:// www.ncbi.nlm.nih.gov/books/NBK557452/
  42. Raza D, Mohiuddin F, Khan MH, Fawad M, Raza SM. Childhood gastroesophageal reflux disease: a comprehensive review of disease, diagnosis, and therapeutic management. World J Clin Pediatr. 2025;14(2):101175. DOI: http://doi.org/10.5409/wjcp.v14.i2.101175
  43. Antunes C, Aleem A, Curtis SA. Gastroesophageal reflux disease (Archived) Treasure Island (FL): StatPearls Publishing; 2025.
  44. Türker SN, Barış Z, Şeker NS, Aydemir Y. Histopathologic differences in pediatric duodenogastric reflux: a comparative study. Eur J Pediatr. 2025;184(6):343. DOI: http://doi.org/10.1007/s00431-025-06163-z
  45. Sharma P, Yadlapati R. Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid. Ann N Y Acad Sci. 2021;1486(1):3-14. DOI: http://doi.org/10.1111/nyas.14501
  46. Yang W, Huang Y, He L. Utilizing esophageal motility tests in diagnosing and evaluating gastroesophageal reflux disease. Diagnostics. 2024;14(14):1467. DOI: http://doi.org/10.3390/diagnostics14141467
  47. Rosen R. Novel advances in the evaluation and treatment of children with symptoms of gastroesophageal reflux disease. Front Pediatr. 2022;10:849105. DOI: http://doi.org/10.3389/fped.2022.849105
  48. Ustaoglu A, Woodland P. Sensory phenotype of the oesophageal mucosa in gastro-oesophageal reflux disease. Int J Mol Sci. 2023;24(3):2502. DOI: http://doi.org/10.3390/ijms24032502
  49. Corovic I, Maksic M, Radojevic D, Vucelj S. Esophageal motility disorders and dysphagia: understanding causes and consequences. IntechOpen. 2024. DOI: http://doi.org/10.5772/intechopen.1006838
  50. Ghamar-Shooshtari A, Rahimian Z, Poustchi H. Polypharmacy and pattern of medication use among patients with gastroesophageal reflux disease: results from Parsi cohort study. BMC Gastroenterol. 2023;23(1):439. DOI: http://doi.org/10.1186/s12876-023-03086-7
  51. Dincer BT, Urganci N, Gulec SG. Drug-induced esophagitis as rare cause of dysphagia in adolescent patients: four case reports. Sisli Etfal Hastan Tip Bul. 2025 Feb 7;59(2):255-257. DOI: http://doi.org/10.14744/SEMB.2024.59196
  52. Hu SW, Chen AC, Wu SF. Drug-induced esophageal ulcer in adolescent population: experience at a single medical center in Central Taiwan. Medicina (Kaunas). 2021;57(12):1286. DOI: http://doi.org/10.3390/medicina57121286
  53. Shutova NA, Kuzmina IYu. Role of adipose tissue and adipokines in chronic inflammation development on metabolic syndrome background. Int Med J. 2021;1:83-87. DOI: http://doi.org/10.37436/2308-5274-2021-15
  54. Luo Y, Luo D, Li M, Tang B. Insulin resistance in pediatric obesity: from mechanisms to treatment strategies. Pediatr Diabetes. 2024;2024:2298306. DOI: http://doi.org/10.1155/2024/2298306
  55. Wang K, Wang S, Chen Y. Causal relationship between gut microbiota and risk of gastroesophageal reflux disease: a genetic correlation and bidirectional Mendelian randomization study. Front Immunol. 2024;15:1327503. DOI: http://doi.org/10.3389/fimmu.2024.1327503
  56. Ciężki S, Odyjewska E, Bossowski A, Głowińska-Olszewska B. Not only metabolic complications of childhood obesity. Nutrients. 2024;16(4):539. DOI: http://doi.org/10.3390/nu16040539
  57. Lu R, Zhou H, Yuan J, Ding Z. Microbiota-gut-brain axis and anxiety or depression: a perspective from bibliometric and visual analysis. Medicine (Baltimore). 2025;104(27):e43221. DOI: http://doi.org/10.1097/MD.0000000000043221
  58. Al-Beltagi M, Saeed NK, Bediwy AS, Elbeltagi R. Breaking the cycle: psychological and social dimensions of pediatric functional gastrointestinal disorders. World J Clin Pediatr. 2025;14(2):103323. DOI: http://doi.org/10.5409/wjcp.v14.i2.103323
  59. Kumar A, Vallabhaneni P. Anxiety disorders presenting as gastrointestinal symptoms in children — a scoping review. Clin Exp Pediatr. 2025;68(5):344-351. DOI: http://doi.org/10.3345/cep.2024.01732
  60. Özenoğlu A, Anul N, Özçelikçi B. The relationship of gastroesophageal reflux with nutritional habits and mental disorders. Hum Nutr Metab. 2023;33:200203. DOI: http://doi.org/10.1016/j.hnm.2023.200203
  61. Ahmed HAA, Yousef A, El-Kurdy R, Murad MA, Abdelwahab SM, Shiba HAA. Psychological factors, lifestyle habits, and their association with gastroesophageal reflux disease among Egyptian university students: a cross-sectional study. Medicine (Baltimore). 2024;103(47):e40477. DOI: http://doi.org/10.1097/MD.0000000000040477
  62. Plaidum S, Patcharatrakul T, Promjampa W, Gonlachanvit S. The effect of fermentable, oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) meals on transient lower esophageal relaxations (TLESR) in gastroesophageal reflux disease (GERD) patients with overlapping irritable bowel syndrome (IBS). Nutrients. 2022;14(9):1755. DOI: http://doi.org/10.3390/nu14091755
  63. Karulina YV, Shevtsova TI. Treatment of Motor Function Disorders of the Upper Digestive Tract in Children with Autonomic Dysfunction. Child’s health. 2024;1:11-16. DOI: http://doi.org/10.22141/2224-0551.19.1.2024.1664
  64. Sliusar N, Volosovets O, Khaustova O, Kryvopustov S. Otsinka tryvozhnosti u ditei z funktsionalnymy hastrointestynalnymy rozladamy, shcho suprovodzhuiutsia abdominalnym bolem, v umovakh voiennoho stanu. Zdorovia dytyny. 2025;20(5):384-391. DOI: https://doi.org/10.22141/2224-0551.20.5.2025.1875 [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 2, 181, 108-115 pages, index UDC 616.329+616.33+616.342]-002-036.12-053.5:616.333/334-008.6:616.839-008.6

DOI:

10.29254/2077-4214-2026-2-181-108-115

Was this article helpful?

Leave a Reply

Your email address will not be published. Required fields are marked *


The reCAPTCHA verification period has expired. Please reload the page.