Pryima M. O., Fedorov S. V.

IMMUNO-INFLAMMATORY INDICES IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AND CONCOMITANT INTESTINAL DYSBIOSIS

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About the author:

Pryima M. O., Fedorov S. V.

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CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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Disturbance of gut microbiota balance is considered an important factor capable of modifying the course of cardiovascular diseases, particularly stable coronary artery disease (CAD). This paper presents the results of a study aimed at determining the relationship between intestinal dysbiosis and key immuno-inflammatory indices that reflect the activity of low-grade chronic inflammation, which in turn is a provoking factor for the development and progression of coronary atherosclerosis. The analysis included 49 individuals with stable CAD, among whom varying degrees of dysbiotic changes were detected in a subset of patients. The evaluation was based on complete blood count parameters with calculation of SIRI, NLR, and MLR, as well as assessment of gut microbiota composition. Comparison between groups demonstrated differences in systemic inflammatory response levels: patients with dysbiosis had higher SIRI and NLR values. Moreover, a gradual increase in SIRI was observed with increasing severity of microbial imbalance, indirectly indicating a dose-dependent influence of dysbiosis on the activation of immuno-inflammatory mechanisms. An interesting finding was the higher prevalence of prior myocardial infarction among patients with dysbiosis, consistent with the hypothesis regarding the role of microbial metabolites and endotoxins in initiating pro-atherogenic processes. The presented results highlight the clinical significance of gut microbiota assessment in the comprehensive evaluation of patients with stable CAD, as the combination of dysbiosis and elevated immuno-inflammatory indices may indicate higher vulnerability to cardiovascular events. Including microbiota parameters in routine clinical assessment may improve risk stratification accuracy and allow earlier identification of patients with potentially unfavorable disease progression. The findings emphasize the need for further studies aimed at assessing whether correction of dysbiosis may serve as an additional therapeutic approach in preventing CAD complications.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 186-194 pages, index UDC 616.34-008.87-092

DOI:

10.29254/2077-4214-2025-4-179-186-194