Hromova A. M., Mitiunina N. I., Shafarchuk V. M., Martynenko V. B., Prylutska N. O., Liakhovska T. Y.
FEATURES OF THE FUNCTIONAL MORPHOLOGY OF THE PLACENTA IN CASE OF PREMATURE AMNIOTIC FLUID DISCHARGE
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About the author:
Hromova A. M., Mitiunina N. I., Shafarchuk V. M., Martynenko V. B., Prylutska N. O., Liakhovska T. Y.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Premature discharge of amniotic fluid creates conditions for ascending infection of the placenta, fetus and newborn, disruption of uteroplacental blood circulation with the subsequent development of fetal distress. The placenta is one of the first barriers that help limit exposure to harmful substances. Dysfunction of the placenta can contribute to complications that increase the morbidity and mortality of both the fetus and the newborn. The study aimed to determine the morphological features of the placenta in case of premature discharge of amniotic fluid. Ninety placentas of women with the premature and timely discharge of amniotic fluid were examined using a standardized method of organo- and morphometry. In 42% of cases, there was a central attachment of the umbilical cord, in 35% (24/69) – lateral and in 1% – membrane. The length of the umbilical cord was 61.6±8.3 cm, and the distance from the place of the membranes to the edge of the placenta was 14.36±3.8 cm. In 41% (28/69) placentas, the course of the vessels was main, in 40% (27/69), it was mixed and in 20% (14/69) dispersed. The intervillous space with the premature discharge of amniotic fluid was empty in only three observation cases (4%). In other cases (96%), it is uneven, in some places sharply narrowed, up to its complete disappearance (the focus of acute infarction). In 10 observations (15%), the intervillous space was centrally expanded with the accumulation of blood and the formation of haemorrhages. In others, it is filled with single erythrocytes and exfoliated syncytial elements. In 8 observations (12%) in the intervillous space, single and concentrated accumulations of segmented nuclear leukocytes were found - focal intervillitis. Early signs of "ageing" of the placenta with the premature discharge of amniotic fluid and disruption of uteroplacental blood flow were revealed. The presence of "infarctions" of the placenta, partial thrombosis, and uneven blood vessels contributed to a synchronous increase in fetal distress.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2023 Issue 2, 169, 178-185 pages, index UDC 618.36:618.414.8
