Lazurenko V. V., Zheleznyakov O. Yu., Horbach T. V., Parkhomenko I. K., Zub O. V., Harkavenko K. V.

FEATURES OF HORMONAL STATUS IN WOMEN WITH OBESITY AND OBSTETRIC AND GYNAECOLOGICAL PATHOLOGY

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Lazurenko V. V., Zheleznyakov O. Yu., Horbach T. V., Parkhomenko I. K., Zub O. V., Harkavenko K. V.

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CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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The study of hormones associated with obesity in women of reproductive age with gynaecological pathology or pregnancy is an urgent task of modern medicine. The study aimed to determine the peculiarities of hormonal status in women with obesity and obstetric and gynaecological pathology to optimise treatment and prevention measures and reduce perinatal complications. A total of 135 women were examined: the first group consisted of 25 (23.8%) women with ovarian cysts (OC); the second group – 30 (28.6%) women with abnormal uterine bleeding (AUB); the third group – 35 (33.3%) pregnant women with GDM; the fourth group included 15 (22.2%) women who were scheduled to undergo bariatric surgery to treat obesity. The control group included 30 women without obesity. It was found that in obese women, the leptin concentration exceeds the control values by 1.6 times, and the presence of gynaecological pathology significantly increases this indicator: in the case of AMC – almost twice, in the case of ovarian tumours – it is 2.7 times. At the same time, in pregnant women with obesity and GDM, the concentration of leptin increases by 3.4 times compared with healthy women of reproductive age. The adiponectin content decreases by 3-5 times, especially in women with III degrees of obesity, who also have the highest insulin concentration, which is almost twice as high as insulinemia in gynaecological patients and obese pregnant women. Thus, patients with obesity and obstetric and gynaecological diseases have disorders in hormone concentrations that affect the general condition of the woman and the state of fatty tissue, the development of obstetric and gynaecological and perinatal complications. Ultrasound measurement of visceral and abdominal fat and their ratio of more than 1.0 indicates a visceral type of obesity, which causes several pathological conditions. Timely implementation of therapeutic and preventive measures aimed at normalising the hormones under study, and, accordingly, obesity, by influencing the psycho-emotional state of a woman, nutritional principles, and optimal physical activity will reduce gynaecological and perinatal morbidity.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 388-397 pages, index UDC 618.1/.2-06-056.257-078:577.17

DOI:

10.29254/2077-4214-2024-4-175-388-397