Sharavara L. P., Dmytrukha N. M.

DISORDERS OF HEMATOLOGICAL INDICATORS IN RATS UNDER THE INFLUENCE OF EXPOSURE TO SUSPENDED ULTRAFINE PARTICLES OF INDUSTRIAL AEROSOL

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About the author:

Sharavara L. P., Dmytrukha N. M.

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HYGIENE, ECOLOGY AND EPIDEMIOLOGY

Type of article:

Scientific article

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The presence of suspended ultrafine particles in the air of the working area of workers in various industries has been proven by numerous studies by scientists and, accordingly, requires a detailed study of the possible toxic effects of these particles on the body of workers. The aim of the study is to investigate changes in haematological parameters of peripheral blood in rats under the influence of suspended ultrafine particles of industrial aerosol. The toxic effect of suspended ultrafine particles, collected at workers' workplaces of machine-building enterprises, was assessed by modelling subchronic intoxication in Wistar rats. Hematological parameters were evaluated at week 6 (after the cessation of the introduction of suspended ultrafine particles) and at week 12 of the experiment (after 6 weeks of recovery period). It was found that changes in haematological parameters of blood were characterised by a decrease in the concentration of haemoglobin, erythrocytes and hematocrit, a decrease in the average volume of erythrocytes at 6 and 12 weeks of the experiment. In all experimental groups of animals, the erythrocyte anisocytosis index increased at week 12 of the experiment compared to the control. The leukocyte formula was characterised by an increase in the number of leukocytes and monocytes and a decrease in the number of lymphocytes. The data obtained from the peripheral blood of experimental animals, based on the results of subchronic intoxication with suspended ultrafine particles of industrial aerosol, were characterised by impaired hematopoiesis, haemoglobin synthesis, and changes in the leukocyte blood formula. These indicate their potential hepatotoxic effect and require further investigation for the implementation of effective preventive measures.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 144-153 pages, index UDC 616.15-008-02:544.772:613.63.02]-092.9:599.323.4

DOI:

10.29254/2077-4214-2025-1-176-144-153