Yevchuk Yu. I., Pantus A. V.

CLINICAL AND EXPERIMENTAL RATIONALE FOR THE FEASIBILITY OF USING A COMBINED FIBRIN–BONE SCAFFOLD WITH A PRONOUNCED LOCAL ANTIMICROBIAL EFFECT

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Yevchuk Yu. I., Pantus A. V.

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DENTISTRY

Type of article:

Scientific article

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The article discusses the effectiveness of a newly developed method for improving the efficiency of bone augmentation in the replacement of bone tissue defects. The aim of this study was to determine the efficacy of restoring jaw- bone defects using an allogeneic–autologous material obtained by the simultaneous centrifugation of demineralised bone substitute granules and the patient’s venous blood. For the clinical study, 90 patients aged 20 to 40 years with radicular cysts of the jaws were selected. All patients were divided into Groups I, II and III, who underwent cystectomy followed by bone grafting. In Group I, a scaffold was used that had been prepared according to the protocol we developed. Microbiological analysis revealed a more pronounced cumulative effect of lincomycin at low concentrations in the pressed plasma fraction (18.75 mg/mL) and in the fibrin matrix (9.4 mg/mL). The results of postoperative clinical and radiological examinations confirmed the effectiveness of the technique we developed. This was evidenced by the high proportion of patients in Group I (83.3%) who achieved complete restoration of the bone defect, which correlated with bone tissue density values ranging from 575.45±20.55 to 636.90±16.64 HU, corresponding to intact bone. In contrast, in Groups II and III, only 16 patients (53.3%) and 13 patients (43.3%), respectively, demonstrated complete restoration of bone tissue. Clinical and radiological analysis thus confirmed the effectiveness of the method we developed, as indicated by positive outcomes in the form of complete bone tissue restoration in 83.3% of patients in Group I, compared with 53.3% in Group II and 43.3% in Group III.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 526-540 pages, index UDC 616.314-71+616.314-089+616.314-007

DOI:

10.29254/2077-4214-2025-3-178-526-540