Poltorapavlov V. A., Koval T. I., Bodnar V. A., Iziumska O. M., Pryimenko N. O., Marchenko O. H., Zdor O. I., Melnyk K. A.

ANTIBIOTICS RESISTANCE OF WOUND MICROFLORA TO ANTIBACTERIAL DRUGS IN PATIENTS OF SURGICAL PROFILE AND MEASURES TO OPTIMIZE THEIR USE

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Poltorapavlov V. A., Koval T. I., Bodnar V. A., Iziumska O. M., Pryimenko N. O., Marchenko O. H., Zdor O. I., Melnyk K. A.

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LITERATURE REVIEWS

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Scientific article

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Antibiotic resistance has long been a priority issue for the WHO. Its urgency is reinforced by the irrational use of antibiotics. Antimicrobial resistance is a threat to global health and causes millions of deaths worldwide every year. The irresponsible and excessive use of antibiotics contributes to the spread of antimicrobial resistance and negatively affects the effectiveness of these critical medicines. Penetrating wounds are the most serious and dangerous. In the case of chest injuries, pneumothorax and hae- mothorax may develop, which can be detected by X-ray examination. Injuries to the abdominal cavity can lead to damage to the hollow and parenchymal organs, as well as intra-abdominal bleeding. In addition, penetrating wounds can cause microorganisms to enter the body cavities (either primarily or secondary to intestinal damage), which can lead to purulent meningitis, pleurisy, peritonitis or arthritis. Analysis and monitoring of microflora isolated from wounds, as well as determining the level of total consump- tion of antimicrobial drugs, are critical links in the diagnostic and treatment process, which is the basis for the correct and rational prescription of antibacterial drugs and prevention of antibiotic resistance. One of the key principles of treatment is the use of an antibiotic that is effective against the microorganisms in the wound. However, sometimes it can take a long time from the time of specimen collection to the time of test re- sults. In such cases, it is recommended to use the antibiotic that has the highest probability of effectiveness against infection, given the characteristics of the purulent discharge. After analysing the wound microflora of patients in the surgical department and determining the range of sen- sitivity of the isolated pathogens to antimicrobials, it is possible to calculate the level of total consumption of an- timicrobials in the department and, based on the data obtained, to propose measures to prevent the spread of antimicrobial-resistant microorganisms. The paper presents generalised data on the analysis of wound microflora of patients in surgical departments, characterises the spectrum of sensitivity of isolated microorganisms to antimicrobial agents, determines the levels of total consumption of antimicrobial agents in the department and suggests measures to prevent the spread of antimicrobial-resistant microorganisms.

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Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 77-101 pages, index UDC 616-001.4-089:615.281.9

DOI:

10.29254/2077-4214-2025-2-177-77-101