Khukhlina O. S., Hryniuk O. Ye., Roshchuk O. I., Liakhovych O. D.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Abstract. The work evaluates the effectiveness of Antral and its effect on fibrotic processes in the liver and lungs. The study included 60 patients with non-alcoholic steatohepatitis (NASH), obesity of I degree and chronic obstructive pulmonary disease (COPD) 2-3B, D, of which 32 patients with COPD 2B (group 1) and 28 patients (group 2) COPD 3D received COPD therapy (Symbicort Turbuhaler (budesonide 160 mg/d + formoterol fumarate 4,5 mg/d) (AstraZeneca AB, Sweden) inhaled 2 times per day for 60 days, Berodual (ipratropium/fenoterol (250/500 mg/ ml) (Institute de Angele Italy / Boehringer Ingelheim International GmbH) nebulizer inhalation 2 times per day, azithromycin (Azithro Sandoz, Ukraine Sandoz) 500 mg, 1 time per day for 10 days) and also they received Antral (Farmak, Ukraine) 200 mg, 3 times per day for 60 days as a hepatoprotector. It was found that in NASH patients with comorbid COPD, which arose against the background of obesity, significantly increased collagen synthesis, respectively, in patients of the 1st and 2nd groups in 2,6 and 3,4 times in comparison with the group of apparently healthy persons (AHP) (p<0,05). These processes were accompanied by a deficiency of hydrogen sulfide, respectively, in 1,5 and 2,8 times (p<0,05) compared with the index in the AHP. Antral, when administered as a course for 60 days to NASH patients against the background of obesity with comorbid COPD, probably inhibits the synthesis of type IV collagen and carbohydrate-protein components of the extracellular matrix of the liver and lungs, probably enhances their degradation and helps restore the pool of hydrogen sulfide in blood. Complex therapy of using Antral helps to inhibit liver fibrosis with a probable decrease in the integral FibroTest indicator by 1,2 times (p<0,05).

non-alcoholic steatohepatitis, obesity, chronic obstructive pulmonary disease, fibrosis, antral.

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«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 148-152 pages, index UDK 616.36-003.826:616-056.527:616.24-007.272]-036.1-07-092-085.244

10.29254/2077-4214-2021-2-160-148-152