Krenov K. Yu., Sukhodolia A. I., Sukhodolia S. A., Loboda I. V.

DYNAMICS OF INTRA-ABDOMINAL PRESSURE LEVELS IN PATIENTS WITH PERITONITIS DEPENDING ON THE IMPLEMENTATION OF INFUSION THERAPY PROGRAMS

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About the author:

Krenov K. Yu., Sukhodolia A. I., Sukhodolia S. A., Loboda I. V.

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CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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Intra-abdominal hypertension can be diagnosed in 55–78% of patients with peritonitis. The aim is to investigate the dynamics of intra-abdominal pressure and hemodynamic parameters following a bolus of infusion solutions in patients with peritonitis and intra-abdominal hypertension. Inclusion criteria: age 18–65 years, duration of illness less than 24 hours, surgical intervention within the first 24 hours, absence of severe decompensated pathology, and grade 1–2 intra-abdominal hypertension. Patients in the first group received 400 mL of a 0.9% NaCl solution at the 30th hour of observation, while those in the second group received 200 mL of a 20% albumin solution at the 30th hour of observation. The study parameters were assessed at the 24th, 30th, 31st, and 36th hours. The results were compared using the t-test, with a significance level of p ≤ 0.05. Statistically significant differences were identified in the analysis of abdominal perfusion pressure, which was lower in the albumin group at the start of the study (P ≤ 0.05). Changes in natriuretic peptide levels did not show statistically significant differences in either the within-group (30th and 31st hours) or between-group analyses. The total infusion volume at the end of the second day was significantly lower in the 20% albumin group, while the dose of vasopressor drugs was significantly lower in the crystalloid group (P≤0.05). The use of 20% albumin administered as a 60-minute bolus in combination with vasopressor therapy using norepinephrine hydrotartrate effectively reduces the total volume of infusion therapy by the end of 48 hours without a statistically significant effect on intra-abdominal pressure, mean arterial pressure, and abdominal perfusion pressure. No statistically significant differences were found between the study groups in terms of urine output, blood product usage, or SOFA scores at 24 and 72 hours. Natriuretic peptide levels did not change significantly in response to the administration of infusion boluses.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 3, 182, 288-293 pages, index UDC 340.624.6:577.1

DOI:

10.29254/2077-4214-2026-3-182-288-293