BIOPHYSICAL FOUNDATIONS OF GADGET-ORIENTED TELEREHABILITATION: TOWARDS STANDARDIZED MULTIMODAL PROTOCOLS IN MODERN PHYSIOTHERAPY IN UKRAINE

Piontkovskyi V. K., Fyk M. I., Ponomaryov V. I., Tkachenko V. V., Sochnieva A. L., Kritsak V. V., Tantsura Ye. O., Tkachenko V. I., Yakovenko S. V., Akhmedova K. M.

BIOPHYSICAL FOUNDATIONS OF GADGET-ORIENTED TELEREHABILITATION: TOWARDS STANDARDIZED MULTIMODAL PROTOCOLS IN MODERN PHYSIOTHERAPY IN UKRAINE


Show/Download

About the author:

Piontkovskyi V. K., Fyk M. I., Ponomaryov V. I., Tkachenko V. V., Sochnieva A. L., Kritsak V. V., Tantsura Ye. O., Tkachenko V. I., Yakovenko S. V., Akhmedova K. M.

Heading:

METHODS AND METHODOLOGIES

Type of article:

Scientific article

Annotation:

Gadget-assisted telerehabilitation has developed rapidly over the past decade, but the heterogeneity of protocols and the focus on individual techniques limit the reproducibility of results and scalability in clinical practice. The aim of this work is to assess the effectiveness of multimodal biophysical telerehabilitation in patients with post-traumatic syndrome. This study summarizes the biophysical foundations, synthesizes clinical data (2019–2025) and develops a standardized multimodal protocol that integrates electrotherapy, PEMF, LIPUS and VR/biofeedback. The systematic review of the PubMed/Scopus databases (2019–2025) was complemented by pilot clinical trials (n=60) conducted using the complex of gadget devices of NTU “KhPI” magnuz-muflon, synchronized with wearable telemetry of smart watches. Key performance indicators: VAS, 6MWT, FEV1, HAM-D, CAPS-5. Clinical cases covered cardiopulmonary, musculoskeletal and neuropsychiatric disorders. The protocols demonstrated stable and clinically significant effects: pain reduction by 32–38%, improvement in mobility by 18–22%, increase in lung function by 12–16%, reduction of psychological symptoms by 25–40%. Patient adherence >85%, frequency of side effects <5%. The study developed step-by-step protocols for the treatment of neurogenic inflammation (analgesia, regeneration, adaptation) and formalized SOPs that include calibration, safety, and telemonitoring using smart watches. Central scientific novelty and practical value. For the first time, a biophysically grounded multimodal model of telerehabilitation based on gadgets, which unifies disparate approaches, has been proposed. The integration of digital twins ensured adaptive dosing and personalized therapy trajectories, while the standardization of SOPs guaranteed reproducibility and readiness for regulatory implementation. This study addresses key methodological gaps by linking medical biophysics to digital health. It offers a baseline for conducting multicenter randomized clinical trials, paving the way for scalable, safe, and effective multimodal telerehabilitation in a variety of clinical contexts.

Tags:

biophysics, electrical stimulation of muscles, electrotherapy, low-intensity pulsed ultrasound, multimodal therapy, percutaneous electrical stimulation of nerves, pulsed electromagnetic fields, telerehabilitation

Bibliography:

  1. Xiao C, Zhao Y, Li G, Zhang Z, Liu S, Fan W, et al. Clinical efficacy of multimodal exercise telerehabilitation based on AI for chronic nonspecific low back pain: randomized controlled trial. JMIR mHealth and uHealth. 2025;13:e56176. DOI: https://doi.org/10.2196/56176
  2. Man SS, Wen H, Chiu KT, Wang F, Chan HS. Effectiveness of telephysiotherapy in improving older adults’ physical and psychological outcomes: systematic review and meta-analysis. Healthcare. 2024;12(17):1775. DOI: https://doi.org/10.3390/healthcare12171775
  3. Pescaru CC, Crisan AF, Marc M, Trusculescu AA, Maritescu A, Pescaru A, et al. A systematic review of telemedicine-driven pulmonary rehabilitation after the acute phase of COVID-19. J Clin Med. 2023;12(14):4854. DOI: https://doi.org/10.3390/jcm12144854
  4. Zhang B, Fang Z, Nian K, Sun B, Ji B. The effects of telemedicine on rotator cuff–related shoulder function and pain symptoms: meta-analysis. J Orthop Surg Res. 2024;19:478. DOI: https://doi.org/10.1186/s13018-024-04986-4
  5. Stamou M, Nikolaou C, Choiras S. Telerehabilitation in physiotherapy science: a scoping review. Cureus. 2024;16(2):e54396. DOI: https://doi.org/10.7759/cureus.54396
  6. Feng Y, Wu Y, Liu H, Bao T, Wang C, Wang Z, et al. Telemedicine-supported multicomponent exercise therapy in patients with knee osteoarthritis: protocol for a randomized controlled trial. Trials. 2023;24:729. DOI: https://doi.org/10.1186/s13063-023-07749-4
  7. Rodríguez Sánchez-Laulhé P, Luque-Romero LG, Barrero-García FJ, Biscarri-Carbonero Á, Blanquero J, Suero-Pineda A, et al. An exercise and educational and self-management program delivered with a smartphone app (CareHand) in adults with rheumatoid arthritis of the hands: randomized controlled trial. JMIR Mhealth Uhealth. 2022;10(4):e35462. DOI: https://doi.org/10.2196/35462
  8. Abedi A, Colella TJF, Pakosh M, Khan SS. Artificial intelligence-driven virtual rehabilitation for people living in the community: a scoping review. npj Digit Med. 2024;7:25. DOI: https://doi.org/10.1038/s41746-024-00998-w
  9. Scott AM, Bakhit M, Greenwood H, Cardona M, Clark J, Krzyzaniak N, et al. Real-time telehealth versus face-to-face management for patients with post-traumatic stress disorder in primary care: a systematic review and meta-analysis. J Clin Psychiatry. 2022;83(4):21r14143. DOI: https://doi.org/10.4088/JCP.21r14143
  10. El-Banna MM, Rizvi MR, Sami W, Sharma A, Atyeh RR. Digital and Intelligent Rehabilitation Technologies in Stroke and Neurological Disorders: A Systematic Review of Artificial Intelligence, Virtual Reality, Gamification, and Emerging Therapeutic Platforms in Neurorehabilitation. Bioengineering. 2026;13(2):195. DOI: https://doi.org/10.3390/bioengineering13020195
  11. Qin H, Du L, Luo Z, He Z, Wang Q, Chen S, Zhu YL, et al. The therapeutic effects of low-intensity pulsed ultrasound in musculoskeletal soft tissue injuries: focusing on the molecular mechanism. Front Bioeng Biotechnol. 2022;10:1080430. DOI: https://doi.org/10.3389/fbioe.2022.1080430
  12. Pescaru CC, Crisan AF, Marc M, Trusculescu AA, Maritescu A, Pescaru A, et al. A systematic review of telemedicine-driven pulmonary rehabilitation after the acute phase of COVID-19. J Clin Med. 2023;12(14):4854. DOI: https://doi.org/10.3390/jcm12144854
  13. Haddad L. Digital rehabilitation: VR and telehealth benefits. J Physiother Phys Rehabil. 2025;10(2):1-3.
  14. Bettger JP, Resnik LJ. Telerehabilitation in the age of COVID-19: an opportunity for learning health system research. Phys Ther. 2020;100(11):1913-1916. DOI: https://doi.org/10.1093/ptj/pzaa151
  15. Glaser R. Biophysics: An introduction. 2nd ed. Berlin: Springer; 2012. 407 p.
  16. Cameron J, Skofronick Jackson H, Grant W. Medical biophysics. Oxford: Oxford University Press; 2018. 343 p.
  17. Su DB, Zhao ZX, Yin DC, Ye YJ. Promising applications of pulsed electromagnetic fields on tissue repair and regeneration. Prog Biophys Mol Biol. 2024;187:36-50. DOI: https://doi.org/10.1016/j.pbiomolbio.2024.01.003
  18. Siwak M, Piotrzkowska D, Skrzypek M, Majsterek I. Effects of PEMF and LIPUS therapy on gene expression related to peripheral nerve regeneration in Schwann cells. Int J Mol Sci. 2024;25(23):12791. DOI: https://doi.org/10.3390/ijms252312791
  19. Zong B, Sun W, Cai C, Shang P. The effects and mechanisms of low-intensity pulsed ultrasound on bone remodeling: from laboratory to clinic. Biomolecules. 2025;15(10):1351. DOI: https://doi.org/10.3390/biom15101351
  20. Gibson W, Wand BM, Meads C, Catley MJ, O’Connell NE. Transcutaneous electrical nerve stimulation (TENS) for chronic pain: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2019;2:CD011890. DOI: https://doi.org/10.1002/14651858.CD011890.pub2
  21. Kontor EK, Wellan C, Maaz HM, Muhammad DG, Al-Qiami A, Sharifan A, et al. Emerging therapeutic modalities and pharmacotherapies in neuropathic pain management: a systematic review and meta-analysis of parallel randomized controlled trials. Pain Res Manag. 2024;2024:6782574. DOI: https://doi.org/10.1155/prm/6782574
  22. Mikołajewska E, Masiak J, Mikołajewski D. Applications of artificial intelligence-based patient digital twins in decision support in rehabilitation and physical therapy: a review. Electronics (Basel). 2024;13(24):4994. DOI: https://doi.org/10.3390/electronics13244994
  23. Legon W, Strohman A. Low‑intensity focused ultrasound for human neuromodulation. Nature Reviews Methods Primers. 2024;4:91. DOI: https://doi.org/10.1038/s43586-024-00368-6
  24. Lee K, Park TY, Lee W, Kim H. A review of functional neuromodulation in humans using low‑intensity transcranial focused ultrasound. Biomedical Engineering Letters. 2024;14:407–438. DOI: https://doi.org/10.1007/s13534-024-00369-0
  25. Wischnewski M, Alekseichuk I, Opitz A. Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation. Trends in Cognitive Sciences. 2023;27(2):189-205.
  26. Elyamany O, Leicht G, Herrmann CS, Mulert C. Transcranial alternating current stimulation (tACS): From basic mechanisms towards first applications in psychiatry. European Archives of Psychiatry and Clinical Neuroscience. 2021;271:135-156. DOI: https://doi.org/10.1007/s00406-020-01209-9
  27. Yang J, Li H, Zhao H, Xie Y, Li J, Wang M. Effectiveness of telerehabilitation in patients with post‑COVID‑19: A systematic review and meta‑analysis of randomized controlled trials. BMJ Open. 2024;14(7):e074325. DOI: https://doi.org/10.1136/bmjopen-2023-074325
  28. Simpson AJ, Green A, Nettleton M, Hyde L, Shepherdson J, Killingback C, et al. Group-based pulmonary telerehabilitation is feasible, safe, beneficial and well-received in patients who have been hospitalised with COVID-19. ERJ Open Research. 2023;9(2):00373‑2022. DOI: https://doi.org/10.1183/23120541.00373-2022
  29. Stewart GM, Wheatley‑Guy CM, Shen WK, Kim C‑H, Johnson BD. Impact of pulsed electromagnetic field therapy on vascular function and blood pressure in hypertensive individuals. Journal of Clinical Hypertension. 2020;22(7):1225-1233. DOI: https://doi.org/10.1111/jch.13877
  30. Fyk MI, Tkachenko VV, Sochnieva AL, Kritsak VV, Tkachenko VI, Tantsura YeO, et al. Bioresonance therapy in the rehabilitation of post-traumatic syndromes using the multiphysics device Muflon-X. Ukrainian Journal of Military Medicine, 2025;6(3):130-139. DOI: https://doi.org/10.46847/ujmm.2025.3(6)-130

Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 2, 181, 228-236 pages, index UDC 615.8:616−001−036.88

DOI:

10.29254/2077-4214-2026-2-181-228-236

Was this article helpful?

Leave a Reply

Your email address will not be published. Required fields are marked *


The reCAPTCHA verification period has expired. Please reload the page.