Hnatyuk M. S., Dovgyy B. I., Tatarchuk L. V., Stets N. Ya., Jasinovskyi O. B.

MORPHOMETRIC STUDY OF STRUCTURAL CHANGES IN VESSELS OF THE HEMOMICROCIRCULATORY BED OF THE URINARY BLADDER AT POSTRESECTION PORTAL HYPERTENSION

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About the author:

Hnatyuk M. S., Dovgyy B. I., Tatarchuk L. V., Stets N. Ya., Jasinovskyi O. B.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

The resection of large volumes of liver parenchyma is complicated by the development of increased pressure in the portal hepatic vein, varicose veins of the oesophagus, stomach, rectum, ascites, splenomegaly, secondary hypersplenism, jaundice, encephalopathy, and multiorgan decompensation. The organs with venous outflow to the vena cavae can also be involved in the pathological process in this complication of portal hypertension. To date, there is no adequate data on the morphogenesis of bladder structures under elevated pressure in the portal system. Microvessels play an important role in the development of organ and system damage when exposed to various toxic factors of endogenous and exogenous origin. The vessels of the bladder microhemocirculatory bed of three groups of laboratory mature male Vietnamese pigs were studied on semi-thin sections: 5 intact animals were included in the first group, 11 pigs with postoperative elevated pressure in the portal hepatic vein were included in the second group, and 6 animals with hypertension in the portal vein system in combination with enteric, hepatic, renal, and heart failure were included in the third group. The pigs were withdrawn from the experiment by bleeding under thiopental-sodium anaesthesia one month after the start of the experiment. Hypertension in the portal hepatic vein was modelled by resectioning the left and right lateral lobes of the liver (60.5% of the liver volume). Microvessels were examined on semi-thin sections of the bladder using quantitative morphology. It was found that one-month postoperative hypertension in the portal vein system leads to a decrease in the lumens of arterioles, precapillary arterioles, hemocapillaries, thickening of their walls, significant dilatation of the postcapillary venules and venules, and thinning of their walls, full blood flow of mainly venous vessels, hypoxia, atrophic, apoptotic, dystrophic, necrobiotic processes in the epithelial cells of the bladder mucosa, myocytes, vascular endothelial cells, connective tissue, foci of cellular infiltration and stromal proliferation. The severity of morphological changes in the bladder microvasculature in laboratory mature male Vietnamese pigs was higher in the combination of postoperative portal hypertension with multiple organ failure.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 405-411 pages, index UDC 616.136.4-003.93-06:616.36-089.87

DOI:

10.29254/2077-4214-2025-1-176-405-411