Chelpanova I. V.

МORPHOLOGICAL AND RADIOLOGICAL ASPECTS OF POST-TRAUMATIC REMODELING OF THE LOWER JAW AFTER OCTACALCIUM PHOSPHATE TRANSPLANTATION

---

Show/Download

About the author:

Chelpanova I. V.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

The issue of finding ways to optimize the course of posttraumatic bone regeneration is very relevant today. The aim of this study was to determine the dynamics of morphological, radiological, and lectin-histochemical characteristics of bone-ceramic regeneration after transplantation of octacalcium phosphate into an experimental defect of the rabbit mandible. The study was conducted on laboratory animals (male rabbits) divided into appropriate groups. Intact animals were used to study the normal structure of the bone tissue of the investigated area of the mandible. The posttraumatic state of the bone tissue in the area of the defect was monitored for 84 days. Morphological examination of the experimental bone defect of the mandible after implantation of osteoplastic material with octacalcium phosphate revealed numerous macroscopic signs of osteoregeneration that correlated with the dynamics of changes in bone surfaces, on radiographs and radiovisiographs and with the lectin-histochemical characteristics of the bone-ceramic regenerate, the peculiarities of the mineral density of the bone tissue of the mandible of the rabbit and the restoration of its quality after implantation of octacalcium phosphate into its cavity were clarified. A fairly high osteoinductive ability of octacalcium phosphate and its effectiveness compared with the control in healing a bone injury under a blood clot were established.

Tags:

Bibliography:

1. Xue N, Ding X, Huang R, Jiang R, Huang H, Pan X, et al. Bone tissue engineering in the treatment of bone defects. Pharmaceuticals. 2022;15:879. DOI: https://doi.org/10.3390/ph15070879.
2. Ferraz MP. Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials. Materials (Basel). 2023;16:4117. DOI: https://doi.org/10.3390/ma16114117.
3. Szwed-Georgiou A, Płociński P, Kupikowska-Stobba B, Urbaniak MM, Rusek-Wala P, Szustakiewicz K, et al. Bioactive materials for bone regeneration: biomolecules and delivery systems. ACS Biomater Sci Eng. 2023;9:5222-54. DOI: https://doi.org/10.1021/acsbiomaterials.3c00609.
4. Migliorini F, Cuozzo F, Torsiello E, Spiezia F, Oliva F, Maffulli N. Autologous bone grafting in trauma and orthopaedic surgery: an evidencebased narrative review. J Clin Med. 2021;10:4347. DOI: https://doi.org/10.3390/jcm10194347.
5. Gillman CE, Jayasuriya AC. FDA-approved bone grafts and bone graft substitute devices in bone regeneration. Mater Sci Eng C. 2021;130:112466. DOI: https://doi.org/10.1016/j.msec.2021.112466.
6. Huang X, Lou Y, Duan Y, Liu H, Tian J, Shen Y, et al. Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances. Bioact Mater. 2024;33:129-56. DOI: https://doi.org/10.1016/j.bioactmat.2023.10.031.
7. Adhikara AG, Maharani AP, Puspitasari A, Nuswantoro NF, Juliadmi D, Maras MAJ, et al. Bovine hydroxyapatite for bone tissue engineering: Preparation, characterization, challenges, and future perspectives. Eur Polym J. 2024;214:113171. DOI: https://doi.org/10.1016/j.eurpolymj.2024.113171.
8. Hamada S, Mori Y, Shiwaku Y, Hamai R, Tsuchiya K, Baba K, et al. Octacalcium phosphate/gelatin composite (OCP/Gel) enhances bone repair in a critical-sized transcortical femoral defect rat model. Clin Orthop Relat Res. 2022;480:2043-55. DOI: https://doi.org/10.1097/CORR.0000000000002257.
9. Jeong C-H, Kim J, Kim HS, Lim S-Y, Han D, Huser AJ, et al. Acceleration of bone formation by octacalcium phosphate composite in a rat tibia critical-sized defect. J Orthop Transl. 2022;37:100-12. DOI: https://doi.org/10.1016/j.jot.2022.09.007.
10. Pyo SW, Paik JW, Lee DN, Seo YW, Park JY, Kim S, et al. Comparative analysis of bone regeneration according to particle type and barrier membrane for octacalcium phosphate grafted into rabbit calvarial defects. Bioengineering. 2024;11:215. DOI: https://doi.org/10.3390/bioengineering11030215.
11. Council of Europe. European Convention for the protection of vertebrate animals used for experimental and other scientific purposes. Strasburg: Council of Europe. 1986;123:52.
12. European Parliament. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes. Off J Eur Union. 2010;53(L276):33-79.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 590-599 pages, index UDC 616.716.4-001-089.843-073.7-018

DOI:

10.29254/2077-4214-2024-4-175-590-599