Stetsuk Ye. V., Levchenko O. A., Shepitko V. I., Boruta N. V.

THE ROLE OF MACROPHAGES IN THE REORGANIZATION OF CONNECTIVE TISSUE OF RAT THIGH MUSCLES UNDER TESTOSTERONE SYNTHESIS BLOCKING (LITERATURE REVIEW)

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About the author:

Stetsuk Ye. V., Levchenko O. A., Shepitko V. I., Boruta N. V.

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LITERATURE REVIEWS

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Scientific article

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To date, the use of synthetic analogues of gonadotropin-releasing hormone to regulate the synthesis of sex hormones has been proven to be more potent and stable than the natural hormone. Releasing hormone antagonists on pituitary gonadotropocytes leads to inhibition of testosterone synthesis in the male body, leading to nitrosative stress in the body tissues. Macrophages are the first cells to respond to changes in tissue homeostasis. The purpose of our work is to determine the role of macrophage type in the reorganization of muscle connective tissue in blocking testosterone synthesis based on the results of the analysis of medical scientific literature based on the databases Scopus, Web of Science, Med Line, PubMed, NCBI over the past 10 years. The literature study showed that the role of macrophages in the reorganization of the connective tissue of the rat thigh muscles when testosterone synthesis is blocked is relevant and requires more detailed study. The issues of changes in the marker proteins S100A8 and S100A9 and p53 during the formation of inflammation in the interstitium in the absence of testosterone activation in muscle tissue remain insufficiently studied. Changes in cellular composition at different stages of oxidative stress in the structure of muscle connective tissue, namely changes in macrophage polarization (M1/M2), with subsequent correction of this pathological condition, require further investigation in accordance with the basic principles of evidence-based medicine.

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 131-140 pages, index UDC 616.748:677.17:612.08:599.323.4

DOI:

10.29254/2077-4214-2024-4-175-131-140