Preys N. I., Savytskyi I. V.
THE ROLE OF NEUROPEPTIDES IN THE DEVELOPMENT OF RETINA NEURODEGENERATION IN RATS UNDER CONDITIONS OF EXPERIMENTAL DIABETIC RETINOPATHY
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About the author:
Preys N. I., Savytskyi I. V.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Long-term hyperglycemia leads to disorders of most metabolic processes, which subsequently leads to an increase in the risk of damage to body tissues, and in the future can cause serious diabetic secondary complications. The purpose of the work is to study the level of neurotrophic factors under the conditions of control pathology and to identify a possible relationship with neurodegenerative changes. The experimental study was carried out on non-linear rats. Were studied the level of protein S100b, brain neurotrophic factor and nerve growth factor, as well as clusterin and fractalin. The study found imbalanced levels of S100b, neurotrophic factor, and nerve growth factor in the serum of rats with diabetic retinopathy, suggesting early signs of retinal neurodegeneration. In particular, the level of serum protein S100b increased by 1.5 times on the 60th day, and by 1.9 times on the 120th day compared to intact animals. The concentration of the neurotrophic factor, both on the 60th and 120th day, exceeded the data of intact animals by 1.2 times, respectively. The level of nerve growth factor significantly increased on the 60th day by 1.2 times, on the 120th day – by 1.5 times relative to intact rats. An increase in the levels of clusterin and fractalin was established, which can be considered prognostic markers in the development of microangiopathic diabetes for early diagnosis of the inflammatory process.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 167-172 pages, index UDC 617.735-002-02:616.379-008.64-085-092.9
