Lukyantseva H. V., Pastukhova V. A., Skorobohatov A. M., Krasnova S. P, Oliinyk T. M., Sosnovskyi V. V., Svirin Yu. R.

PECULIARITIES OF SKELETAL BONE MORPHOGENESIS ON THE BACKGROUND OF PROLONGED ADMINISTRATION OF TARTRAZINE IN CONDITIONS OF BONE DEFECT

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About the author:

Lukyantseva H. V., Pastukhova V. A., Skorobohatov A. M., Krasnova S. P, Oliinyk T. M., Sosnovskyi V. V., Svirin Yu. R.

Heading:

PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

Type of article:

Scientific article

Annotation:

One of the pathogenetic factors of post-traumatic osteoregeneration disorders is the chronic use of food additives as part of food products. One such substance is the yellow dye tartrazine (E102), information on its effect on the rates of osteogenesis and bone regeneration is scarce, which actualized the appearance of our research. In the experiment, the effect of E102, simulation of a bone defect, and the combined effect of both factors on the rate of bone growth in rats were investigated. Modeling the defect in the bones leads to deterioration of the linear and transverse growth of the humerus. E102 adversely affects the intensity of osteogenesis processes, and appositional bone growth suffers more compared to longitudinal bone growth. The combined action of bone defect modeling against the background of long-term exposure to tartrazine leads to the most significant negative consequences on bone growth rates, which is determined by the synergistic adverse effect of both factors.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 2, 173, addition, 33-35 pages, index UDC 519.443:[613.648.4+613.37

DOI:

10.29254/2523-4110-2024-2-173/addition-33-35