Tverdokhlib I. V., Marchenko D. G.

PRENATAL CHANGES IN THE CONTRACTILE APPARATUS OF RAT VENTRICULAR MYOCARDIUM AFTER CHRONIC ALCOHOL INTOXICATION OF MATERNAL ORGANISM

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About the author:

Tverdokhlib I. V., Marchenko D. G.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

The object of research was the hearts of rat embryos and fetuses from the 14th day of prenatal ontogenesis to birth. Quantitative parameters of cardiomyocyte myofibrils in different zones of the ventricular myocardium were determined using transmission electron microscopy. It has been established that chronic alcohol intoxication of the maternal organism leads to inhibition of sarcomerogenesis and general damage of the spatial organization of the contractile apparatus of ventricular cardiomyocytes of embryos and fetuses. On the 14th day of embryogenesis, the absolute particular surface area of myofibrils and the degree of their orientation are significantly lower than normal values in different zones of the myocardium. In the period from the 14th day of embryogenesis to birth, the processes of alteration of cardiomyocyte contractile apparatus are manifested to varying degrees depending on the localization. In newborn rats after intrauterine exposure to alcohol, the absolute particular surface area of myofibrils in cardiomyocytes of the intramural zone exceeds normal values by 36.7% (p<0.05) in the left ventricle and by 35.8% (p<0.05) in the right ventricle. The values of the degree of myofibril orientation in the composition of all zones of the myocardium of both ventricles are significantly lower than normal values. The greatest damage is observed in the intramural zone of the free wall of both ventricles.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 443-449 pages, index UDC 611.12:611.018:611.013:576.311.348.3

DOI:

10.29254/2077-4214-2024-1-172-443-449