Munko M. A.
EFFECT OF THE ANTICOAGULANT ENOXAPARIN DIRECT ACTION ON THE METASTATIC ACTIVITY OF LEWIS LUNG CARCINOMA
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About the author:
Munko M. A.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Metastasis is the leading cause of death in patients with cancer. The spread of the tumor process to distant sites occurs mainly through the bloodstream. Tumor growth and aggressiveness largely depend on the ability of cancer cells to cause neoangiogenesis and metastasis. Special attention is paid to the study of various pathological changes in the hemostatic system in cancer patients to improve treatment outcomes by assessing the value of hypercoagulability markers and the coagulation framework of the tumor cell in treating this category of patients. The aim of the experiment was to investigate the effect of a direct-acting anticoagulant, an antithrombotic drug of the LMWH group, enoxaparin at a dose of 10.0 mg/kg on the metastatic activity of Lewis lung carcinoma (LL), transplanted into male C57BL/6 mice by subcutaneous injection for 20 days and to assess pathological changes in platelet hemostasis, whole blood coagulation activity and their relationship with metastasis progression. Under conditions of enoxaparin administration at a dose of 10.0 mg/kg against the background of metastatic tumor growth on day 28 of the study, a significant reduction in the metastatic activity of Lewis lung carcinoma was found. A comparative analysis of the platelet component of the hemogram and the coagulation activity of whole blood of experimental animals with LL carcinoma revealed a significant reduction in blood clotting time, pathological enlargement of the spleen (splenomegaly), which is a consequence of increased platelet sequestration and an increase in the splenic pool, causing thrombocytopenia. At the same time, enoxaparin therapy at a dose of 10.0 mg/ kg is accompanied by a significant increase in blood clotting time and an increase in the number of platelets in the blood of experimental mice.
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 194-203 pages, index UDC 615.273.53+616-006.08
