Poladych I. V., Govsieiev D. O.

VITAMIN D DEFICIENCY AS A RISK FACTOR FOR PREECLAMPSIA: THE ROLE OF VITAMIN D RECEPTOR AND CYTOCHROME P450 FAMILY 27 SUBFAMILY B MEMBER 1

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Poladych I. V., Govsieiev D. O.

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CLINICAL AND EXPERIMENTAL MEDICINE

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Scientific article

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Preeclampsia is a serious pregnancy complication that can have dangerous consequences for both the mother and the fetus. It is associated with vascular dysregulation, hypertension, and the potential development of complications such as preterm birth and intrauterine growth restriction. One of the potential risk factors for preeclampsia is vitamin D deficiency, as confirmed by our study involving 98 pregnant women at the Kyiv Perinatal Center. It was found that low vitamin D levels (<20 ng/mL) were more frequently observed in younger women (28,86±0,67 years) with an increased body mass index (27,85±0,34 kg/m²). Analysis of placental tissue revealed reduced expression of the vitamin D receptor (VDR) gene (0,95 (0,91–1,08)) and CYP27B1 (1,04 (0,96–1,12)), as well as decreased levels of the corresponding VDR (2,32 (1,11–2,52) ng/mL) and CYP27B1 (4,34 (4,20–5,15) ng/mL) proteins. Vitamin D deficiency was associated with a more severe course of preeclampsia (58,3% of cases) and its early onset (<34 weeks in 63,9% of women). The findings highlight the importance of regular monitoring of vitamin D levels in pregnant women and timely correction of its deficiency to reduce the risk of preeclampsia and improve pregnancy outcomes.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 288-297 pages, index UDC 618.3/.5-06:616.12-008.331.1-07-085:577.161.2

DOI:

10.29254/2077-4214-2025-1-176-288-297