Kucherenko T. O., Nekhanevych Zh. M., Gudaryan O. O.Jr.
THE ROLE OF CHANGES IN sICAM-1 INDICATOR AND MARKERS OF CONNECTIVE TISSUE METABOLISM IN PATIENTS WITH PERI-IMPLANT MUCOSITIS AND INITIAL STAGE OF PERI-IMPLANTITIS
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About the author:
Kucherenko T. O., Nekhanevych Zh. M., Gudaryan O. O.Jr.
Heading:
DENTISTRY
Type of article:
Scientific article
Annotation:
Symptoms of an inflammatory reaction in the gingival tissues in peri-implant mucositis and early peri-implantitis are the leading indicators in the clinical picture. However, current clinical and paraclinical criteria often do not allow for accurate diagnostic monitoring, especially regarding the transitional state from mucositis to peri-implantitis. All this points to the need to develop new, more sensitive markers and diagnostic methods that more effectively monitor the severity of the inflammatory process in peri-implant tissues and detect changes in their condition in a timely manner. Preclinical diagnostics of the early stages of peri-implantitis is an urgent task of modern dentistry. Destruction of collagen in the area of connective tissue attachment in the apical area of the dental implant can be an indicator of these conditions. The study of markers of connective tissue metabolism in the initial stages of mucositis and peri-implantitis is of great importance, as it contributes to the timely detection and treatment, preventing more severe complications. The study analysed the intercellular adhesion molecule sICAM-1 level, free and protein-bound oxyproline in 43 patients with peri-implant mucositis and 22 patients with the initial stage of peri-implantitis. It was found that the concentration of sICAM-1 in the blood in the range of 289.4-328.6 ng/ml is an indicator of the intensity of the inflammatory process in the body. An increase in free oxyproline level and a decrease in protein-bound oxyproline indicate destructive changes in the peri-implant tissues. The assessment of these biomarkers in the blood allows for a more accurate prediction of the likelihood of peri-implant mucositis progression to peri-implant disease at the initial stages of diagnosis.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 665-672 pages, index UDC 616.314.7-007:616.716.4-085-089
