Kolosova I. I.

OVARIAN TOXICITY OF CADMIUM CHLORIDE: MECHANISMS AND CONSEQUENCES

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About the author:

Kolosova I. I.

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PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

Type of article:

Scientific article

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The article summarizes current scientific evidence on the effects of cadmium chloride on the structural and functional state of the ovaries. Experimental and clinical data demonstrate that cadmium is among the the most potent reproductive toxicants capable of disrupting multiple ovarian processes. Particular attention is given to key mechanisms of cadmium - induced ovarian toxicity, including oxidative stress, impairment of folliculogenesis, sup- pression of antioxidant defense enzymes, and damage to granulosa and theca cells. The review highlights cadmium- related disturbances in steroidogenesis, alterations in hormonal balance, impaired oocyte maturation and increased follicular atresia. Special emphasis is placed on the ability of cadmium to accumulate in ovarian tissue, displace essential metals, interfere with mitochondrial function, and trigger regulated cell death pathways. The article also outlines exposure routes, bioavailability patterns, and factors determining cadmium accumulation in the reproduc- tive system. The need for further research is emphasized, particularly regarding the long- term consequences of cadmium exposure and the search for potential protective agents capable of mitigating its detrimental effects on female reproductive health.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 7-9 pages, index UDC 612.3: 591.39: 661.852: 661.782-092.9

DOI:

10.29254/2523-4110-2025-4-179/addition-7-9