Kyryk Kh. A., Podoliuk M. V., Hresko N. I., Mykhalevych M. M., Logash M. V., Bekesevych A. M.

MORPHOMETRIC CHARACTERISTICS OF THE STATE OF THE HEMOMICROCIRCULATORY BED OF THE VASCULAR LAYER OF THE EYEBALL AT 6 WEEKS OF DIABETES MELLITUS (EXPERIMENTAL INVESTIGATION)

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About the author:

Kyryk Kh. A., Podoliuk M. V., Hresko N. I., Mykhalevych M. M., Logash M. V., Bekesevych A. M.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

According to the definition of the WHO expert group, diabetes mellitus, as a pandemic of the 21st century, oc- cupies a leading place among the causes of disability of the able-bodied population of economically developed countries. In view of this, scientific research aimed at a thorough study of structural and ultrastructural changes in tissues and organs in experimental models has gained priority. Laboratory rats of the Wistar line were chosen as the latter. The presented experimental study is aimed at finding morphometric changes in the hemomicrocirculatory bed of the choroid of the eyeball of rats under conditions of artificially induced diabetes mellitus with streptozotocin in the period from 6 weeks from the onset of the disease. Considering the predominant lesion of the vascular link, we focused on the morphometric analysis of the angioarchitectonics of the eyeball, which is the basis for assessing the degree of pathological changes in its vascularization under conditions of diabetes mellitus. The experiment proved that compensatory mechanisms are not able to reduce the scale of destruction of the links of the hemomicrocir- culatory bed of the choroid of the eyeball of white rats and the specified changes naturally pass into the stage of irreversible ones. In addition, we noted a clear trend of growth in morphological changes in the structural elements of the choroid of the eye, the findings were characterized by direct correlative relationships with the duration of the pathology, and, accordingly, the severity of the disease. After 6 weeks of the experiment, we found that the destruction of the choroid of the eyeball was at the stage of morphological decompensation, and the capillaries of the membrane underwent significant destructive perturbations, while the arterioles acquired a tortuous structure, with impaired patency and uneven lumen. No less significant were pathological deviations of the capillary link of the ciliary processes, we observed frequent phenomena of capillary obliteration, atrophic changes in the capillary com- ponent of the hemomicrocirculatory bed, and also identified fragments of individual capillaries completely deprived of their basic functions.

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Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 429-437 pages, index UDC 611.842-076.1-08

DOI:

10.29254/2077-4214-2025-2-177-429-437