Fomina L. V., Verkholantsev D. S.

MORPHOLOGICAL CHANGES IN THE SMALL INTESTINAL WALL AND ITS MICROBIOTA UNDER CONDITIONS OF ACUTE ISCHEMIA

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About the author:

Fomina L. V., Verkholantsev D. S.

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PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

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Scientific article

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The small intestine is a unique ecological niche within the digestive tract where all physiological conditions are specifically established: rapid content transit, the secretion of pancreatic enzymes, bile acids, and intestinal glands, a comparatively low microbial biomass, and a complex immune system. Small intestinal ischemia is a critical pathological condition characterized by a sharp reduction in the blood supply to the intestinal wall, resulting in profound structural and functional derangements. Currently, this represents a crucial challenge in both clinical gastroenterology and experimental morphology. The aim of the study is to analyze scientific literature over the last 10 years regarding the morphological changes in the small intestinal wall and its microbiota under the influence of experimental ischemia. The study analyzes experimental ischemia models, the nature of histological damage, microcirculation disorders, interrelations with dysbiosis, mechanisms of injury, and potential therapeutic approaches. Promising directions for further research are also considered.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 68-71 pages, index UDC 611. 341 : 616. 34 : 579. 2

DOI:

10.29254/2523-4110-2025-4-179/addition-68-71