Kucherenko T. O., Nekhanevych Zh. M., Samoilenko I. A., Yunkin Y. O., Dorogina O. S.

INCREASING THE EFFICIENCY OF OSTEOINTEGRATION OF DENTAL IMPLANTS IN PATIENTS WITH LOW ALVEOLAR BONE DENSITY USING RISEDRONATE SODIUM

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About the author:

Kucherenko T. O., Nekhanevych Zh. M., Samoilenko I. A., Yunkin Y. O., Dorogina O. S.

Heading:

DENTISTRY

Type of article:

Scientific article

Annotation:

Recently, one of the most common methods of treating secondary adentia is dental implantation, which has become possible thanks to affordable prices, a large number of manufacturers, and the increasing skill of implant surgeons. The quality of bone tissue, especially its density, determines the process of osseointegration. Computed tomography is widely used for diagnosis, allowing the assessment of bone anatomy and density, as well as the selection of implantation technique. However, the problem of local osteoporosis is relevant because it disrupts the bone's microarchitecture, reduces the stability of implants, and can lead to rejection. The use of risedronate sodium is being tested to improve the stability and osseointegration process of implants. The aim of this study was to evaluate the clinical and laboratory results of using risedronate sodium in patients with low alveolar bone density. The study population consisted of 53 patients with secondary adentia and bone type D4. Patients with generalised periodontitis were divided into two groups: a comparison group of 26 individuals and a main group of 27 individuals, totalling 53 participants. Laboratory research methods included biochemical markers of bone formation and bone resorption. Immunochemiluminescence analysis was used to determine N-osteocalcin levels. To determine markers of bone metabolism and C-terminal telopeptides (β-CTx), the solid-phase enzyme immunoassay method was used. The mean value in Groups I and II was 310.2±15.2 HU and 312±14.9 HU, respectively – bone type D4 according to Mish. In both groups, eight patients had disintegration of 14 implants. Instability in 100% of cases at the stage of installing gum formers (stage II), in patients of Group II (8 patients – 12 implants), and in one patient of Group I, 2 implants disintegrated. Risedronate sodium significantly improves bone mineral density and increases the success rate of dental implant osseointegration in patients with low bone density.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 547-556 pages, index UDC 616.314-089.843:611.018.4]-07-085.27

DOI:

10.29254/2077-4214-2025-3-178-547-556