Mamai O. V., Bilash S. M.
HEMODYNAMIC CHANGES IN MORPHOMETRIC PARAMETERS OF CENTRAL ARTERIES OF SPLEEN LYMPHOID FOLLICLES UNDER THE INFLUENCE OF A COMPLEX OF CHEMICAL FOOD ADDITIVES IN THE EARLY STAGES OF THE EXPERIMENT
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About the author:
Mamai O. V., Bilash S. M.
Heading:
PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH
Type of article:
Scientific article
Annotation:
A special, though sometimes underestimated, component of the immune system is the spleen, which, according to some observations of scientists, is considered a “forgotten” organ. The importance and role of the spleen, in our opinion, is absolutely necessary in maintaining and regulating, not only in the context of the universal organ of hematopoiesis in the fetus and maintaining the stable composition and properties of blood, but also as an organ that is crucial in ensuring antigen-dependent differentiation of T and B lymphocytes. In addition, the state of the spleen hemomicrocirculatory system, which is directly involved in the above processes, requires further study to understand the pathophysiological mechanisms of the effect of a complex of chemical food additives on the biological structures of the immune system. The study was conducted on 40 mature rats, which were divided into one control and three experimental groups. The control group received saline, and the experimental group received a complex of chemical food additives (monosodium glutamate, sodium nitrine, Ponceau 4R) at doses two times lower than the maximum permissible doses. After weeks 1, 4, and 8 of the experimental study, the experimental animals were withdrawn from the experiment by an overdose of ether anesthesia. It has been established that the administration of a complex of food chemical additives to white experimental rats after 1 week leads to compensatoryrestorative processes in the form of significant vasodilation of the central arteries of spleen lymphoid follicles. After 4 and 8 weeks, the opposite effect occurs - a sharp narrowing of the arteries, i.e. vasoconstriction, which may indicate destructive changes in the spleen lymphoid follicles of white laboratory rats due to the action of a complex of chemical food additives.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 2, 173, addition, 36-38 pages, index UDC 611.41/428:611.136.42:613.29]-092.9-021.67
