Senko S. V., Nebesna Z. M.

FEATURES OF THE ILEUM STRUCTURAL REMODELING IN WHITE RATS UNDER CONDITIONS OF DMH-INDUCED IN SITU COLON ADENOCARCINOMA

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About the author:

Senko S. V., Nebesna Z. M.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

Diseases of the digestive system are among the leading causes of chronic morbidity and reduced quality of life, which determines their high medical and social significance. Pathology of the small intestine occupies a special place, since structural and functional disorders of this segment underlie disturbances of digestion, absorption, and immune homeostasis. Investigation of the pathomorphological changes of the small intestine is essential for deepening the understanding of the pathogenesis of digestive system diseases, as well as improving their early diagnosis and treatment. The aim of the study was to investigate microscopic changes in the wall of the ileum in white rats under conditions of DMH-induced carcinogenesis. The experimental study was performed on 85 outbred mature male white rats. Microscopic examination of the ileum in animals with modeled colon oncogenesis revealed pronounced alterative-degenerative changes in all tunics of the intestinal wall, with predominant involvement of the mucosa. These included destruction and desquamation of the epithelium, deformation and reduction of villi and crypts, foci of acute necrosis, marked edema, impaired microcirculation, and massive histoleukocytic infiltration with lymphoid tissue hyperplasia. Involvement of the muscular and serous tunics accompanied by disorganization of smooth myocytes indicates a severe and widespread lesion of the ileum under conditions of experimental carcinogenesis.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 342-349 pages, index UDC 616.345-006.6:616.34-091:616-092.9:599.323.4

DOI:

10.29254/2077-4214-2025-4-179-342-349