Shevchenko T. M., Govorukha O. Yu.
EVALUATION OF CYTOLOGICAL RESEARCH METHODS FOR CERVICAL CANCER DIAGNOSIS
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About the author:
Shevchenko T. M., Govorukha O. Yu.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
The task of studying pathological conditions of the cervix, diagnosing and treating them is one of the most urgent and essential tasks of modern gynaecological practice. Obviously, diseases of the genital reproductive system are a significant problem, occurring in 10-15% of women of reproductive age. Among all visits to gynaecologists, precancerous diseases of the cervix account for 35 to 80% and not tend to decrease. We studied the indicators of laboratory methods for diagnosing the condition of the cervical epithelium and the records of patients' medical records. For the study, a group of women who underwent a gynaecological examination at the MNPE Ternivka Central City Hospital TCC was selected - 130 people. The control group consisted of 20 healthy women with no pathological changes in the cervix. The study was conducted by the traditional method of cytological examination using artificial dyes and with the help of an Eyre spatula or a Cecilian brush. In 57 patients (44% of women) of the study group, in contrast to the examined patients of the control group, a cytogram of inflammation was noted. The number of patients infected with herpes zoster virus in the study group was 13% (17 women). A small number of women (2%) (3 patients) with trichomonas inflammation was also detected. Also, during the examination of patients, 25 patients (19% of women) were found to have mild cervical intraepithelial neoplasia (CIN 1). In 23 female patients (18%), a moderate degree of cervical intraepithelial neoplasia and moderate dyskaryosis were noted. Fourteen patients (11% of patients) had severe cervical intraepithelial neoplasia.
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Bibliography:
- Zaporozhan VM, Tsehelʹsʹkyy MR. Hinekolohichna patolohiya: Atlas. Odesa: Odes. derzh. med. un-t; 2002. 308 s [in Ukrainian].
- Zaporozhan VN. Akusherstvo y hynekolohyya. K.: Zdorov’ya; 2001. 820 s.
- Likhteynshteyn AV, Kiseleva NP. Biokhimiya. K.; 2001. Chast’, Metilirovaniye DNK i kantserogenez; s. 293-317.
- Baay MF, Duk JM, Groenier KH, Burger MP, de Bruijn HW, Hollema H, et al. Relation between HPV-16 serology and clinic-pathological data in cervical carcinoma patients: prognosis value of anti-E6 and/or anti-E7 antibodies. Cancer. Immunology. Immunotherapy. 1997;44:211- 215.
- Bos AB, van Ballegooijen M, van den Akker-van Marle ME, Hanselaar AG, van Oortmarssen GJ, Habbema JD. Endocervical status Is not predictive of the Incidence of cervical cancer in the years after negative smears. Am. J. Clin. Pathol. 2001;115:851-855.
- Chan AO, Kim SG, Bedeir A, Issa JP, Hamilton SR, Rashid A. CpG Island Methylation in carcinoid and pancreatic endocrine tumors. Oncogene. 2003;13:924-934.
- Arends MJ, Buckley CH, Wells M. Etiology, pathogenesis, and pathology of cervical neoplasia. J. Clin. Pathol. 1998;51:96-103.
Publication of the article:
«Bulletin of problems biology and medicine», 2023 Issue 3, 170, 320-327 pages, index UDC 618.146-006-076
