Oleksiienko V. V. Bilash S. M.

ASSESSMENT OF THE DEVELOPMENT OF OXIDATIVE STRESS IN GINGIVAL TISSUES UNDER NITRITE INTOXICATION DURING EXPOSURE TO A COMPLEX OF CHEMICAL FOOD ADDITIVES

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About the author:

Oleksiienko V. V. Bilash S. M.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

Today, given the constant growth in demand for food products, manufacturers are increasingly using various methods to speed up production processes and increase product shelf life. One of the most common approaches to achieving these goals is the use of chemicals, in particular food additives. At the same time, there is a proven negative impact of additives on the body. The experiment was conducted to study morphological changes in the gums under the influence of a complex of food additives and to identify changes in the development of compensatory reactions depending on the concentration of nitrites. The concentration of malondialdehyde (MDA) was determined as a marker of lipid peroxidation and, accordingly, oxidative stress. It was found that the MDA concentration increased in waves during the experiment, with compensatory-adaptive reactions occurring in the early stages of the study (4-8 weeks) and a significant increase in MDA at 12-16 weeks of the experiment after the compensatory reactions disappeared. In the later stages of the study, increased nitrite levels indicated impaired compensatory and adaptive responses and increased toxic stress on gum tissue. A similar dynamic was observed in nitrite concentration, which initially showed a sharp increase, followed by a short-term decrease during the period of adaptation of the body to the effects of harmful substances, and subsequently showed the development of persistent nitrite intoxication. High nitrite levels in the later stages of the experiment indicate a disruption in the mechanisms of their elimination and excretion from the body, which only increases the toxic load on the gum tissue.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 334-342 pages, index UDC 616.311.2: 641:612.3-071

DOI:

10.29254/2077-4214-2025-4-179-334-342