Kutserov V. R., Gavrylіuk V. G., Kurahina N. V., Lavrentіeva K. V., Sklyar T. V., Zubareva I. M.

ANALYSIS OF THE DISTRIBUTION OF BACTERIAL ETIOLOGY RESPIRATORY INFECTION PATHOGENS IN CHILDREN OF DIFFERENT AGE GROUPS

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Kutserov V. R., Gavrylіuk V. G., Kurahina N. V., Lavrentіeva K. V., Sklyar T. V., Zubareva I. M.

Heading:

MICROBIOLOGY

Type of article:

Scientific article

Annotation:

This study aims to analyze the species spectrum of bacterial pathogens causing respiratory tract infections in children of different age groups, identify the dominant etiological agents, and establish their antibiotic resistance profiles. As a result of microbiological research conducted in 179 children aged 0-17 years with diseases of various parts of the respiratory tract, the etiological structure of the most significant pathogens of infectious lesions was determined. The frequency of their isolation was as follows: 51.9% of cases – Haemophilus influenzae, 15.7% – Klebsiella pneumoniae, 9.5% – Pseudomonas aeruginosa, 5.6% – Stenotrophomonas maltophilia, 6.1% of cases – Streptococcus pneumoniae. It has been shown that the most vulnerable age groups for pathogens of acute respiratory diseases of the upper and lower respiratory tract are children under 3 years of age (34% and 46% of cases, respectively), while adolescents aged 13 to 17 years are the most vulnerable age groups for chronic infections of the upper and lower respiratory tract (57% and 31% of cases, respectively). The circulation of antibiotic-resistant variants of Haemophilus bacteria has been established in children with respiratory diseases, which were more frequently detected in chronic forms (54.5% of cases). High levels of resistance to penicillin and fluoroquinolone drugs have been demonstrated, with lower levels of resistance to cephalosporins. Multiple-resistant isolates of Haemophilus bacteria to 2-5 antibiotics were detected in both chronic (21.2%) and acute (15.6%) infections. The data obtained demonstrate the necessity of continuous monitoring of the etiological structure, the nature of manifestations, age-specific development of infections in various parts of the respiratory tract, and the circulation of antibiotic-resistant variants of disease-causing agents in hospital populations. These data are important for developing preventive and therapeutic measures and for advancing research programs aimed at protecting children's health.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 263-274 pages, index UDC 616.34-002.1:579.61

DOI:

10.29254/2077-4214-2025-4-179-263-274