Drin I. T
ACCUMULATION OF HEAVY METALS IN THE BLOOD OF PATIENTS WITH OVARIAN CANCER
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About the author:
Drin I. T
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Today, despite the development of medicine and the improvement of pharmaceuticals, the treatment of patients with stage III and IV ovarian cancer remains insufficiently effective. Modern methods of treating these patients are accompanied by insufficient survival, which requires the identification of additional prognostic factors to individualize treatment. In a retrospective analysis of clinically similar groups of patients, ovarian cancer is characterized by significant heterogeneity in the course and response to treatment, which necessitates the search for new prognostic factors. The aim is to evaluate the effect of chromium, cadmium, copper, plumbum, and zinc in the blood of ovarian cancer patients on the relapse-free period's duration. The study was based on observing 131 patients with ovarian cancer; the control group consisted of 10 people who were not diagnosed with malignant tumors of any localization. The study participants provided written informed consent to participate in the study. The studied metals in patients blood were determined using the method of atomic absorption determination of micro- and macroelements in ash solutions of biological materials. Copper, zinc, and chromium have been shown to impact progression-free survival, while cadmium and plumbum content do not affect the duration of remission. According to the data obtained, zinc has the highest impact on the duration of recurrence-free survival of patients with ovarian cancer (p < 0.001) - the regression coefficient is 0.54 with a standard error of 0.09, that is, with an increase in the content of this metal in the blood of patients, the duration of survival is significantly longer. Compared to zinc, chromium and copper have a significantly lower effect on recurrence-free survival. Thus, with an increase in chromium content in patients' blood and a decrease in zinc and copper, a shorter duration of disease-free survival is observed. In the future, it is planned to study the content of the above heavy metals in the tumor tissue of patients with ovarian cancer.
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Publication of the article:
«Bulletin of problems biology and medicine», 2023 Issue 3, 170, 203-209 pages, index UDC 616-037+616-006.6+618.11
