The aim was to study the features of psycho-emotional and cognitive functions in patients with PD stage II using neuropsychological and neurophysiological examination. Materials and methods. The study included 90 patients aged 49 to 75 years with PD II stage according to Hoehn-Yahr and 30 people without signs of extrapyramidal pathology. The severity of PD was assessed using the MDS UPDRS scale. Psychoemotional status was assessed using the Beck Depression Scale, the Spielberger-Hanin Anxiety Scale, and the Hospital Anxiety and Depression Scale. Cognitive function was assessed by the MMSE Scale. Cognitive evoked potential (CEP) of the auditory stimulus P300 was investigated in the Odd-ball paradigm event model with the patient considering a significant stimulus among the insignificant ones. Leads F3, F4, NW, C 4, P3 and P4 were used to analyze the P300 instrumentation. The main indicators for the analysis of P300 were the latency period of the N 2 peaks, which is associated with the recognition of the stimulus in the temporal zone, and P300, which is associated with the stage of stimulus perception, as well as the amplitude of the N 2 / P300 peak. Results. Neuropsychological examination of patients revealed cognitive impairment in 67.78 % of patients, and the MMSE score in patients with PD stage II was significantly lower (p=0.02) compared with the assessment of patients in the control group. The latent period of the N 2 and P300 peaks of the P300 CEP was significantly (p<0.001) longer, and the N 2/P300 peak amplitude was significantly lower (p<0.001) in patients with PD stage II compared to the control group in frontal, central and parietal leads bilaterally. It was found that in patients with PD without clinical symptoms of cognitive impairments latent period of peaks N 2 and P300 CEP P300 was also significantly longer, as well as the amplitude of the peak N 2/P300 lower compared to similar indicators of the control group. A negative moderate correlation was found between the MMSE ‘Concentration’ Subscale and the latency period of the N 2 peak and between ‘Random access memory’ Subscale and the latent period of the P300 peak in all study leads. Conclusions. The MMSE ‘Concentration’ and ‘Random access memory’ Subscale score is the lower, the longer the latency peaks in N 2 and P300, respectively, in the frontal, central, and parietal leads of the P300. In patients with PD stage II, there is a significant increase in the latency period of the N 2 and P300 peaks, decrease in the amplitude of the N 2 / P300 peak and MMSE score compared to healthy individuals, which manifested by impaired ability to concentrate attention and decreased random access memory.
«Bulletin of problems biology and medicine» Issue 2 Part 1 (164), 2022 year, 158-169 pages, index UDK 616.858–008.6:612.821.5]-073.97
