This article describes the historical aspects of the origin and development of chronobiology and chronomedicine. Laws and value of biological rhythms, rhythmic processes and their impact on various organs and systems at various levels. Of the possibility of chronomedicine to predict the flow of various diseases and preven- tion of their complications. Thus, chronomedicine is at the junction of science: medicine (diagnosis and treatment), chronobiology (development and substantiation of theoretical concepts) and mathematics (developing methods of mathematical analysis of rhythmic manifestations). Today biological rhythms is revealed in all living organisms, from the simplest and ending with man. It is also said that the current research in various fields of science and technology, in particular, medicine show that the development of many human diseases, depends, to a greater extent, violation of natural biological rhythms that regulate the function of all cells and tissues of the body. Cyclicality of life processes has long been interested in people. The concept of rhythm is one of the most important in ancient Chinese medicine. It is based on the alternation of In and Yang, as well as on the change of the seasons, day and night, lunar months, and so on. Rhythms associated with the concept of time: physical, biological, understood as the corresponding evolution in phylogenesis. Chronobiology – branch of biology that studies the conditions for the occurrence, nature, patterns and signifi- cance of biological rhythms, explores rhythmic processes at different levels of organization of all living things: cell- free systems, cell, single-celled organisms, cell and tissue culture, multicellular animals and plants, populations of organisms. Chronomedicine (like chronobiology) – a young, interdisciplinary research area, which is in the process of be- coming. In chronomedicine find their methods of mathematical processing of time series, which are used for the analysis of rhythmic manifestations of physiological processes of the body currently challenge young, relatively recently emerging sciences – chronobiology and chronomedicine (subsections) are primarily research related to improving the diagnosis, prevention and treatment of pathological conditions in humans. We can say that in many areas of medicine, to a certain extent, the inclusion of progressing in the diagnosis, planning and treatment indi- vidualization chronomedicine laws. At the same time, these problems in dentistry, virtually no attention. Hronodiag- nostichesks methods allow us to predict the disease at the so-called pre-clinical stage, when not yet developed the disease. That is to change the default human rhythms already indicates that something is wrong. If we examine the various rhythms of cells, tissues and organs of the body, we can see some violations at the earliest stages, including the development of dental pathology. This is a promising direction in our opinion so far not developed. However, we can assume that the character of the course of many inflammatory processes, injuries governed by the laws of chronobiology. For example, the literature describes the diurnal variations of oral fluid pH and its influence on the structure of the tooth enamel, the activity of organs and systems of the body, that is, oral fluid is of chronobiological object having certain patterns of change in physiological parameters and obeys the laws of rhythmic organization. In the special literature there is practically no information about the chronobiological aspects of dentistry, so it is advisable to develop this subject at the present stage in order to develop possible methods for predicting the course and the complications of different kinds of dental diseases, taking into account their development under the laws of chronomedicine.
«Bulletin of problems biology and medicine» Issue 3 part 1 (110), 2014 year, 296-299 pages, index UDK 616. 31:57. 034 (092)
